5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde(CAS#881674-56-2)
Introduction
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Yellow to reddish-brown crystals or powders with a peculiar odor.- Solubility: Solubility is good in common organic solvents such as ethanol, chloroform and methylene chloride.Use:5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde is commonly used as an intermediate in the synthesis of organic fluorescent dyes, photosensitizers and pesticides.Method:A common method for the synthesis of 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde is to react pyrrole-3-carboxaldehyde with 2-fluoroaniline under alkaline conditions to produce a target product. The reaction process is usually carried out in an appropriate solvent such as acetonitrile and requires the appropriate temperature and time.Safety Information:- Irritation to the skin and eyes, avoid exposure to the skin, eyes, or inhalation.- When using or storing, appropriate safety measures should be taken, such as wearing appropriate protective clothing and gloves, and enhancing ventilation.- Avoid contact with oxidants, strong acids, strong alkalis, etc., to prevent dangerous chemical reactions.
Application
5‑(2‑Fluorophenyl)‑1H‑pyrrole‑3‑carboxaldehyde (CAS 881674‑56‑2) is the key intermediate and advanced building block in the industrial synthesis of Vonoprazan fumarate, a first‑in‑class potassium‑competitive acid blocker (P‑CAB) used to treat gastric ulcers, duodenal ulcers, reflux esophagitis, and other acid‑related disorders. The ortho‑fluorophenyl group and the 3‑formylpyrrole scaffold are also valuable in building pyrrole‑based kinase inhibitors, anticancer agents, and other enzyme modulators. The aldehyde handle supports condensation reactions, reductive amination, and cross‑couplings (e.g., Suzuki‑Miyaura) to create diverse therapeutic libraries, while the fluorine atom increases metabolic stability and lipophilicity for improved pharmacokinetics. In quality control, this compound serves as Vonoprazan Carbaldehyde Impurity, an essential reference standard for analytical method development (AMD), method validation (AMV), ANDA filings, and impurity profiling in commercial API production. Xinchem offers custom synthesis and contract manufacturing of high‑purity (>98.5%) 5‑(2‑fluorophenyl)‑1H‑pyrrole‑3‑carboxaldehyde, scaled reliably from R&D gram quantities to commercial metric tons. Contact us for a competitive quote and a reliable global supply.
