3-Pyridinesulfonyl chloride(CAS#16133-25-8)
| Risk Codes | R34 - Causes burns R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3261 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
Introduction
Pyridine-3-sulfonyl chloride is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of pyridine-3-sulfonyl chloride:Quality:- Appearance: Pyridin-3-sulfonyl chloride is a colorless to pale yellow liquid.- Solubility: Soluble in organic solvents such as ethers, alcohols and chlorinated hydrocarbons.Use:- Pyridin-3-sulfonyl chloride is a commonly used reagent in organic synthesis for the introduction of pyridine sulfonyl chloride groups, and is commonly used as an esterification, acetal, and alkylation reaction reagent for aromatic hydrocarbons and aryl boronic acids.Method:- Pyridine-3-sulfonyl chloride can be formed by the reaction of pyridine and thionyl chloride.Safety Information:- Pyridine-3-sulfonyl chloride is irritating and can cause inflammation and irritation in contact with the skin and eyes. Care should be taken to use personal protective equipment such as laboratory gloves and goggles during contact.- It is also a flammable liquid and should be used in a well-ventilated area and away from open flames and heat sources.
Application
3-Pyridinesulfonyl chloride (CAS 16133-25-8) is a key pharmaceutical intermediate used in the synthesis of Vonoprazan Fumarate, a potassium-competitive acid blocker (P-CAB) for the treatment of gastric ulcers, duodenal ulcers, and reflux esophagitis. Its reactive sulfonyl chloride group readily undergoes nucleophilic substitution with amines to form sulfonamide derivatives, enabling the preparation of diverse drug candidates, including sulfonamide antibiotics and antidiabetic agents. This versatile building block also serves as a reagent for synthesizing pyrimidine derivatives that exhibit anti-proliferative activity against triple-negative breast cancer cells. Beyond pharmaceuticals, it is applied in the production of dyes, agrochemicals (pesticides), and functional materials. Its role as a catalyst precursor further expands its utility in organic synthesis. Xinchem offers custom synthesis and contract manufacturing of high-purity 3-Pyridinesulfonyl chloride with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
