Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2(CAS#158563-45-2)
Introduction
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, also known as nonapeptides (Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2), are synthetic peptides of nine amino acids. The following is a description of the nature, use, preparation and safety information of the Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2:
Properties: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is a white crystalline powder, can be dissolved in solution. It has a high molecular weight and a complex three-dimensional structure.
Purpose: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 are widely used in biomedical research. It can mimic natural neuropeptides, such as endorphin and β-endorphin, which play an important role in the biological function of nerve cells. Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is considered to have anti-inflammatory, antioxidant, antibacterial, analgesic and neuroprotective activities. Some of its applications include treatment of nerve damage, neurodegenerative diseases, and pain management, among others.
Preparation Method: The Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is usually prepared by a chemical synthesis method. During synthesis, nine amino acids are linked in a specific order to form the structure of the nonapeptide.
Safety information: According to current research, Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 are considered relatively safe under general conditions of use. However, as with all compounds, care should be taken in the method of use and dosage control when using the Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2. Further research is needed to understand the potential effects and safety of Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 in humans. Before using Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, it is recommended to consult a professional doctor or an appropriate authoritative guide for information on its scope of application, contraindications and side effects.
Application
Nonapeptide-1 (Melanostatine-5, CAS 158563-45-2) is a synthetic peptide hormone that functions as a highly selective competitive antagonist of the melanocortin 1 receptor (MC1R), with a Ki of 40 nM. By binding to MC1R, it effectively blocks α‑melanocyte stimulating hormone (α‑MSH)-induced intracellular cAMP accumulation (IC50 = 2.5 nM) and melanosome dispersion in melanocytes (IC50 = 11 nM). This dual mechanism potently inhibits tyrosinase activation and subsequent melanin synthesis, making Nonapeptide-1 a valuable active ingredient in advanced skin care and cosmetic formulations. It is widely incorporated into whitening and spot‑correcting products, including serums, creams, lotions, and masks, to reduce hyperpigmentation, even out skin tone, and prevent the formation of age spots and melasma. As a biomimetic peptide with excellent safety and efficacy profiles, Nonapeptide-1 is also utilized as a research tool in dermatological studies for skin pigmentation disorders. Xinchem offers high‑purity Nonapeptide-1 with flexible custom synthesis, custom chemical synthesis, and contract manufacturing services, supporting reliable global supply from R&D samples to commercial volumes. Contact us for a competitive quote today.







