4,4,4-TRIFLUOROBUT-2-EN-1-OL(CAS#674-53-3)
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, FLAMMABLE |
Introduction
Properties of 4,4,4-Trifluoro-2-buten-1-ol:- Appearance: Colorless liquid- Solubility: Can be dissolved in water and organic solventsUse of 4,4,4-Trifluoro-2-buten-1-ol:4,4,4-Trifluoro-2-buten-1-ol is a raw material for organic synthesis, which has a wide range of applications in chemical synthesis.Preparation method of 4,4,4-trifluoro-2-buten-1-ol:The synthesis method of 4,4,4-trifluoro-2-buten-1-ol is mainly obtained by the reaction of hydrofluoric acid (HF) and acrolein (C3H4O).Safety information of 4,4,4-trifluoro-2-buten-1-ol:- 4,4,4-Trifluoro-2-buten-1-ol is an organic substance that is toxic and should be used with caution.- Contact with skin, eyes, or taking may cause irritation, burns, or damage. Care should be taken to avoid contact during operation.- Wear protective gloves and eyes when using and ensure that the operation is carried out in a well-ventilated area.- In case of accidental contact, rinse immediately with plenty of water and seek medical attention.- When storing and handling, avoid contact with oxidants and combustibles, as well as avoid high temperatures and ignition sources.- Decomposition may occur during long storage periods, and its stability should be checked regularly.
Application
4,4,4-Trifluorobut-2-en-1-ol is a versatile trifluorinated allylic alcohol building block serving as a key pharmaceutical intermediate and agrochemical reagent. It is widely used as a lead compound to develop potent acetylcholinesterase inhibitors for Alzheimer's and Parkinson's disease research. In drug discovery, this compound functions as a building block for introducing fluorinated alcohol groups into drug candidates, leveraging the trifluoromethyl group to improve metabolic stability, target binding, and lipophilicity. As a strategic agrochemical intermediate, it is highly valuable for producing fluorinated herbicides, where the trifluoromethyl group enhances water solubility and field stability of active ingredients. This product also participates in cross-coupling reactions, including metal-free isomerization to β-trifluoromethyl ketones. Xinchem offers this high‑purity fluorinated intermediate with reliable custom synthesis and contract manufacturing, scaled from R&D to commercial tons. Contact us for a competitive quote.
