4,4,4-Trifluorocrotonic acid ethyl ester(CAS#25597-16-4)
| Risk Codes | R10 - Flammable R36/37 - Irritating to eyes and respiratory system. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29161900 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
Ethyl 4,4,4-trifluorobutenolate, also known as TFBE, is an organic compound. The following is an introduction to the nature, use, manufacturing method and safety information of TFBE:Quality:- Appearance: TFBE is a colorless liquid.- Solubility: TFBE is soluble in common organic solvents.Use:- As a solvent: TFBE is an organic solvent with a low surface tension that can be used to dissolve substances such as colloids, coatings, and resins.- Intermediates in chemical reactions: TFBE can be used as an intermediate in chemical reactions for the synthesis of olefins and esters in organic synthesis, e.g. for the preparation of fluorinated organic compounds.Method:The preparation method of TFBE is complex, generally synthesized by esterification of 2,2,3,3-tetrafluoroacetone (TFA) and ethanol, and a catalyst needs to be added during the reaction process, and the target product is obtained by distillation and purification.Safety Information:- TFBE is an organic compound and should comply with relevant safety operating procedures.- TFBE has a lower toxicity but is still an organic solvent and may have adverse health effects if exposed to or inhaled in excess.- Avoid contact with skin, eyes, and respiratory tract during use, and use with appropriate protective measures such as safety glasses, gloves, and respiratory protective equipment.- If you experience excessive contact or inhalation, seek medical attention promptly.
Application
Ethyl 4,4,4-trifluorocrotonate is a versatile fluorinated building block and α,β-unsaturated ester that serves as a key pharmaceutical and agrochemical intermediate. It is widely employed in diastereoselective Michael addition reactions to construct complex molecules bearing trifluoromethyl groups, which significantly enhance the metabolic stability, lipophilicity, and bioavailability of drug candidates. This reagent is used in the synthesis of bioactive heterocycles, including novel trifluoromethylpyroglutamic acid derivatives and amino trifluoromethyl cyclopropanecarboxylic acid analogs. In medicinal chemistry, it facilitates the preparation of enzyme inhibitors and other therapeutic agents. In crop protection, it enables the development of fluorinated agrochemicals with improved biological activity and field persistence. Its high purity ensures reproducible results in complex organic transformations, SAR studies, and GMP-compliant process development. Xinchem offers custom synthesis and contract manufacturing of high-purity Ethyl 4,4,4-trifluorocrotonate with flexible scaling from R&D to commercial tons, supported by global supply capabilities. Contact us for a competitive quote today.
![(4R,12aS)-7-(benzyloxy)-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione(CAS#1206102-09-1)](https://www.xinchem.com/uploads/benzyloxyb.png)
