(R)-(+)-A-methyl 4-nitrobenzylamine hydrochloride(CAS#57233-86-0)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
Introduction
(R)-α-methyl-4-nitrobenzylamine hydrochloride is an organic compound with the chemical formula C8H10N2O2 · HCl. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: White solid (crystal)
-Melting Point: 173-175°C
-Solubility: Soluble in water, soluble in organic solvents
Use:
-As an intermediate in organic synthesis: It can be used to synthesize other organic compounds, such as drugs and pesticides.
-Used for photochemical excitation: It can also be used for photochemical reactions and photosensitive chemical reactions.
Preparation Method:
(R)-α-methyl-4-nitrobenzylamine hydrochloride can be synthesized by a variety of methods. The following is a common synthesis method:
1. 4-nitrobenzylamine reacts with o-methyl benzoyl chloride to generate α-methyl -4-nitrobenzylamine under appropriate conditions.
2. The obtained α-methyl-4-nitrobenzylamine is reacted with hydrochloric acid to produce (R)-α-methyl-4-nitrobenzylamine hydrochloride.
Safety Information:
-It should avoid contact with strong oxidants and strong acids to avoid dangerous reactions.
-During use and storage, normal chemical laboratory safety practices should be followed, including the wearing of appropriate personal protective equipment, such as lab gloves and glasses.
-If necessary, operate in a well-ventilated area to avoid inhalation of dust and skin contact.
-It should be stored in a dry, cool place, away from flames and heat sources.
Application
(R)-α-Methyl-4-nitrobenzylamine hydrochloride is a high-purity chiral primary amine widely used as a versatile pharmaceutical intermediate, organic synthesis building block, and asymmetric synthesis precursor. It functions as a chiral resolution reagent to separate racemic compounds, enabling the production of enantiomerically pure active pharmaceutical ingredients (APIs) for treating neurological disorders and other therapeutic areas. As a synthetic building block, its amine moiety undergoes nucleophilic substitution, acylation, and reduction (nitro to amino), facilitating access to chiral cyclopalladated complexes for enantioselective catalysis and optically active drug candidates. It also serves as a precursor for photochemical excitation in specialty chemical research and is utilized as a reference standard in impurity profiling for chromatographic quality control. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity chiral intermediate, scaled flexibly from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
