1-(cyclopropylcarbonyl)-Monohydrochloride(CAS#1021298-67-8)
Introduction
1-Cyclopropylpiperazine hydrochloride is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:1-Cyclopropylpiperazine hydrochloride is a white crystalline solid that is soluble in water and alcohol-based solvents. It is a weakly basic compound and reacts with acids to form salts.Use:1-Cyclopropylpiperazine hydrochloride is often used as a chemical reagent and intermediate. It can also be used as a buffer and surfactant.Method:1-Cyclopropylpiperazine hydrochloride can usually be prepared by the reaction of piperazine and cyclopropionyl chloride. Cyclopropionyl chloride and piperazine are reacted under appropriate conditions, and hydrochloric acid is then added to generate 1-cyclopropylpiperazine hydrochloride.Safety Information:1-Cyclopropylpiperazine hydrochloride has a good safety profile under normal operating conditions. As a chemical, the following are still important to be aware of:- Avoid prolonged exposure to skin, eyes, and mucous membranes, and avoid inhalation or ingestion. Protective gloves, goggles, and a mask are required to operate.- Maintain a well-ventilated laboratory environment during use.- When storing, it should be placed in a dry, cool, ventilated place, away from fire sources and flammable substances.
Application
1-(Cyclopropylcarbonyl)piperazine hydrochloride is a high-purity piperazine-based pharmaceutical intermediate and building block widely used in drug discovery and process development. It serves as a key pharmaceutical intermediate in the convergent synthesis of Olaparib (Lynparza®), a first-in-class PARP inhibitor for treating BRCA-mutated ovarian and breast cancers, where the cyclopropylcarbonyl-piperazine moiety is essential for high PARP1/2 selectivity and potent antitumor activity. This building block is also utilized as an advanced intermediate for allosteric TYK2 inhibitors, including Deucravacitinib (Sotyktu®) for autoimmune diseases (e.g., psoriasis), and as a reference standard for analytical method development (AMD), method validation (AMV), quality control (QC), and impurity profiling for ANDA filings. The compound’s amine group and cyclopropyl ring enable orthogonal functionalization, supporting rapid structure-activity relationship (SAR) studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
