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2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol(CAS#207679-81-0)
2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol(CAS#207679-81-0)
Physicochemical properties
It is generally white or off-white crystalline powder, which has a certain solubility in organic solvents such as methanol, ethanol, methylene chloride, etc., and is slightly soluble in water.
Structural features
The molecule contains a benzene ring with a chiral (R)-3-(diisopropylamino)-1-phenylpropyl side chain attached to the 2 positions and a hydroxymethyl group attached to the 4 positions. Among them, the diisopropyl amino group has a certain alkalinity, and the benzene ring and hydroxymethyl groups make the molecule have a certain hydrophilicity and chemical reactivity.
Fields of application
Pharmaceutical intermediates: It is an important intermediate in the synthesis of some drugs for the treatment of urological diseases, such as in the process of synthesizing tolterodine tartrate and other drugs, (R)-5-hydroxymethyl tolterodine is one of the key intermediates, which participates in the construction of the molecular structure of the drug and plays an important role in the activity and selectivity of the drug.
Drug impurity reference substance: It can be used as an impurity reference for drugs such as fesolodine, which is used in drug quality control and analysis and testing, and determines the presence and content of impurities in the drug by comparing it with drug samples to ensure the quality and safety of the drug.
Application
Application
(R)-5-Hydroxymethyl Tolterodine (PNU-200577, Desfesoterodine, CAS 207679-81-0) is the major pharmacologically active metabolite of the antimuscarinic drugs Tolterodine and Fesoterodine. It acts as a potent and selective muscarinic receptor (mAChR) antagonist with a Kb of 0.84 nM, exhibiting functional selectivity for the urinary bladder over salivary glands in vivo. As a critical pharmaceutical intermediate and advanced organic building block, it is directly used in the convergent synthesis of Fesoterodine Fumarate, a first‑line prodrug for overactive bladder (OAB) and urinary incontinence. This high‑purity (≥98%) chiral compound serves as a key reference standard for impurity profiling, analytical method development (AMD), method validation (AMV), and Quality Control (QC) applications for Abbreviated New Drug Applications (ANDA) and commercial production. In drug metabolism and pharmacokinetics (DMPK) research, it is a validated reference metabolite for CYP2D6 phenotyping and drug‑drug interaction studies. It is also employed as a building block for other therapeutic candidates targeting urological and central nervous system (CNS) disorders. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this pharmaceutical building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
