4,6-Diamino-2-mercaptopyrimidine(CAS#1004-39-3)

Introduction

4,6-Diamino-2-mercaptopyrimidine is an organic compound, often abbreviated as DAF. It has the following properties:Appearance: White crystalline solid.Solubility: Soluble in water and some organic solvents.Chemical properties: 4,6-diamino-2-mercaptopyrimidine is a reducing agent with good reducing and oxidizing properties.Its main uses:Biological research: as a fluorescent probe for the detection of aerobic reduction reactions and active argon ions, etc.Chemical analysis: used as an analytical reagent for the detection and analysis of metal ions, organic compounds, etc.Common methods for the preparation of 4,6-diamino-2-mercaptopyrimidine are as follows:Sulfhydrylation: A sulfhydryl reagent (e.g., mercaptoacetic acid) is used to react with pyrimidines to generate 4,6-diamino-2-mercaptopyrimidine.Reduction reaction: A reducing agent (e.g., hyposulfoxide) is used to reduce the compound to produce 4,6-diamino-2-mercaptopyrimidine.4,6-Diamino-2-mercaptopyrimidine is a chemical and should be followed in accordance with appropriate laboratory practices and avoid direct contact with the skin and eyes.Wear appropriate protective equipment, such as lab gloves, goggles, etc., when in use.Contact with oxygen should be avoided during storage to prevent the occurrence of oxidation reactions.When disposing of waste, it should be disposed of appropriately in accordance with local environmental regulations.

4,6-Diamino-2-mercaptopyrimidine (DAMP, CAS 1004-39-3) is a highly functionalized sulfur-containing pyrimidine derivative with two free amino groups and a reactive thiol group. This heterocyclic building block exhibits diverse biological activities and chemical versatility, making it a valuable pharmaceutical intermediate in medicinal chemistry. In anticancer research, its derivative SCR7 is a potent DNA Ligase IV inhibitor that disrupts non-homologous end joining (NHEJ) repair pathways, enhancing cytotoxicity in cancer cells. DAMP also demonstrates antimicrobial properties against resistant bacterial strains and serves as a precursor for antiplatelet agents. In coordination chemistry, it acts as an N,S-bidentate ligand for synthesizing silver, zinc, and cobalt coordination polymers that show excellent catalytic activity in Hantzsch polyhydroquinoline synthesis with high reusability. MOFs constructed with DAMP as an organic linker exhibit antibacterial, antibiofilm, and antioxidant activities. DAMP is also an effective corrosion inhibitor for copper and mild steel by forming a protective adsorption layer on metal surfaces. Additionally, it functions as an analytical reagent for metal ion detection, a fluorescent probe for hydrogen sulfide sensing, and a reducing agent in chemical analysis. In agrochemical R&D, DAMP derivatives are explored as herbicides and fungicides. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity (≥98%) 4,6-Diamino-2-mercaptopyrimidine with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.