6-Amino-3-methyluracil(CAS#21236-97-5)

Introduction

6-Amino-3-methyluracil is an organic compound.Quality:6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione is a colorless crystalline powder that is soluble in water and some organic solvents. It is a neutral compound and does not possess acidity and alkalinity. The crystallized 6-amino-3-methylpyrimidine-2,4(1H,3H)-dione has high thermal stability and low toxicity.Use:6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione has a wide range of applications. It can also be used as a catalyst and catalytic reagent in organic synthesis. 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione can also be used in the preparation of chemical products such as dyes, coatings, and adhesives.Method:There are two main ways to prepare 6-amino-3-methylpyrimidine-2,4(1H,3H)-dione. One is obtained by the reaction of methylleucine and cyanamide under alkaline conditions. The other is prepared by the methylation reaction of uracil.Safety Information:6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione is relatively safe under general conditions of use, but general laboratory practices should be followed when used or stored. It is irritating to the eyes and skin and needs to be avoided. Appropriate personal protective equipment such as laboratory gloves and protective glasses should be worn when handling this compound.

Application

6-Amino-3-methyluracil (CAS 21236-97-5) is a versatile pyrimidine‑derived building block, widely utilized as a pharmaceutical intermediate and reference standard. It serves as a key precursor to 5-acetylamino‑6-amino‑3‑methyluracil (AAMU), the major urinary metabolite of caffeine, and acts as an authorized impurity reference standard for alogliptin, making it essential for analytical method development (AMD), method validation (AMV), quality control (QC), and ANDA submissions. As a catalyst or intermediate, it is employed in the synthesis of aminomethylbenzene and in the construction of heterocyclic pharmacophores such as pyrido‑, pyrrolo‑, and pyrimido‑pyrimidines. Its derivatives are under investigation for neuroprotective activity, including bifunctional acetylcholinesterase inhibition for Alzheimer’s research. Additionally, this compound is explored for antimicrobial, antioxidant, and DNA‑repair‑inhibiting applications, as well as for the synthesis of enzyme inhibitors and bioactive nucleoside analogs. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity 6‑Amino‑3‑methyluracil with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.