6-Amino-1-methyluracil(CAS#2434-53-9)

Introduction

6-Amino-1-methyluracil is an organic compound with the chemical formula C5H7N3O2. It is a derivative of uracil with a single amino and methyl substituent. The following is a description of the properties, uses, formulation and safety information of 6-Amino-1-methyluracil:

Nature:

-Appearance: 6-Amino-1-methyluracil is a white solid

-Solubility: It is soluble in water, can also be dissolved in some organic solvents

-Melting point: Its melting point range is 232-236 degrees Celsius

-Stability: Relatively stable under regular conditions, but avoid exposure to strong light or high temperature conditions to prevent decomposition.

Use:

-Pharmacy: 6-Amino-1-methyluracil can be used as a synthetic intermediate for some drugs, such as anticancer drugs, antiviral drugs and immunomodulators.

-Cosmetics: It can also be used in the cosmetics industry as an antiviral and anti-inflammatory ingredient for the production of skin care products and cosmetics.

Method:

6-Amino-1-methyluracil can be prepared by a number of synthetic routes. Commonly used methods include Amination of uracil or nucleophilic substitution of uracil. Specifically, uracil can be reacted with methylamine or a methylating agent to give 6-Amino-1-methyluracil.

Safety Information:

- 6-Amino-1-methyluracil requires personal protection when handling, including wearing gloves, protective glasses and laboratory coats.

-It is a low-toxic substance, but it is still necessary to avoid inhaling, swallowing or touching the skin. When using or handling, appropriate protective measures should be taken to prevent adverse effects on the body.

-When handling this compound, store it in a dry, well-ventilated place, away from fire and oxidizing agents.

-In the event of an accident, seek medical attention immediately and present information about the compound to the doctor so that appropriate countermeasures can be taken.

Application
6-Amino-1-methyluracil (CAS 2434-53-9) is a key pyrimidine derivative and a versatile building block widely used in pharmaceutical research and drug development. Structurally, it is an amino-modified uracil analog that serves as a critical pharmaceutical intermediate in the synthesis of xanthine derivatives, including theophylline, caffeine, and other methylxanthine-based APIs. As a certified reference material, it is essential for analytical method development (AMD), method validation (AMV), and quality control (QC) applications for Abbreviated New Drug Applications (ANDA) and commercial production of xanthine drugs. This compound has demonstrated significant biological activity, functioning as a thymidylate synthetase inhibitor, thereby preventing DNA replication and transcription, which leads to cell death. It also exhibits inhibitory effects towards DNA repair glycosylase, making it valuable in oncology research for developing cancer therapeutics. In medicinal chemistry, 6-amino-1-methyluracil serves as a scaffold for synthesizing novel heterocyclic compounds, including spiro-fused pyrimidoquinoline derivatives via reaction with isatin. Its derivatives have shown potent inhibitory activity against acetylcholinesterase (AChE), positioning them as promising candidates for Alzheimer's disease research. Additional applications include its use as a plant growth regulator in agriculture, a component in diagnostic assays for biomarker detection, and a monomer in specialty polymer development. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 6-Amino-1-methyluracil, with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.