Ethyl 4-chlorocrotonate(CAS#10479-85-3)
Ethyl 4-chlorocrotonate(CAS#10479-85-3)
Structural features
The molecule contains carbon-carbon double bonds and ester groups, which have the typical structural characteristics of olefins and esters. The carbon-carbon double bond makes the molecule have a certain degree of unsaturation, and can undergo addition, oxidation and other reactions; The ester group gives the molecule a certain polarity and reactivity, and can undergo hydrolysis, alcohololysis, ammonolysis and other reactions.
use
Organic synthesis intermediates: can be used to synthesize a variety of organic compounds, such as through the addition reaction with compounds containing active hydrogen, the introduction of ethyl 4-chlorobutanate group, the construction of new carbon-carbon bonds or carbon-heterobonds, and further synthesis of organic compounds with special structures and functions. It can also be used as a starting material for the synthesis of some pharmaceutical intermediates, providing an important basis for drug research and development.
Material synthesis: In the synthesis of some polymer materials, it can participate in the polymerization reaction as a functional monomer, introducing specific functional groups into the polymer, thereby improving the properties of the polymer, such as improving the flexibility, heat resistance, and water resistance of the polymer.
Application
Ethyl 4-chlorocrotonate (CAS 10479-85-3) is a versatile bifunctional α,β-unsaturated ester containing an allylic chlorine group. It serves as a key pharmaceutical intermediate and building block in drug discovery. The compound acts as an alkylating agent for constructing heterocyclic scaffolds such as pyrazoles, pyrimidines, and pyrroles, which are core structures in anticancer, antiviral, and antimicrobial agents. It is also used in the synthesis of amino acid derivatives via nucleophilic substitution and in agrochemical development for fungicides and herbicides. Its dual reactivity—the α,β-unsaturated ester for Michael additions and the chlorine for SN2 displacement—enables orthogonal functionalization of complex molecules. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity Ethyl 4-chlorocrotonate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
