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tert-butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate(CAS#871726-73-7)
Introduction
1,4,5,7-Tetrahydro-6H-pyrazolo[3,4-C]tert-butyl pyridin-6-carboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless crystalline solidUse:- 1,4,5,7-Tetrahydro-6H-pyrazolo[3,4-C]tert-butyl pyridin-6-carboxylic acid can be used as an intermediate in organic synthesis for the synthesis of other organic compounds.Method:- Tert-butyl ester of 1,4,5,7-tetrahydro-6H-pyrazolo[3,4-C]pyridin-6-carboxylic acid can be prepared by a series of organic synthesis reactions. The specific preparation method may involve multi-step reactions and intermediates of different compounds.Safety Information:- It is an organic compound and should be used in accordance with routine laboratory safety operating procedures.- Avoid contact with skin and eyes, and make sure to operate in a well-ventilated area.- It can be toxic to humans and should be kept away from children and pets.- Appropriate personal protective measures, such as gloves and respirators, should be taken during handling and storage.
Application
tert-Butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate (CAS 871726-73-7) is a 6-azaindazole scaffold and a key pharmaceutical intermediate for targeted kinase inhibition. It serves as a potent inhibitor of tropomyosin receptor kinases (TRKs), blocking cell proliferation pathways such as Ras/Erk and PI3K/Akt for oncology R&D. Additionally, this heterocyclic building block supports the synthesis of HPK1 inhibitors for cancer immunotherapy, RIP1 kinase inhibitors for neuroinflammatory diseases, and selective GSK3α/β, CLK1, and DYRK1A inhibitors with validated sub-micromolar activity. Its unique N-6 geometry enables distinct hinge-region binding within ATP pockets, offering selectivity over the common [3,4-b] regioisomer. Beyond kinase inhibitor design, it is utilized in fragment-based drug discovery (FBDD), agricultural chemistry for pesticide and herbicide development, and material science for high-performance coatings. This Boc-protected dihydropyrazolopyridine enables efficient functionalization at N-1, N-2, C-3, C-5, and C-7 positions via cross-coupling reactions. Xinchem provides high-purity tert-butyl pyrazolo[3,4-c]pyridine-6-carboxylate with flexible custom synthesis, custom chemical synthesis, and contract manufacturing scaled from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
![(4R,12aS)-7-(benzyloxy)-9-broMo-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione(CAS#1206102-10-4)](https://www.xinchem.com/uploads/benzyloxy.png)
