2-(3,4-diMethoxyphenyl)-3-hydroxy-4H-chroMen-4-one(CAS#6889-80-1)

Introduction

Quality:2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-benzopyran-4-one is an organic compound. The substance is a yellow solid with a peculiar aromatic odor.Use:2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-benzopyran-4-one has certain application value in the field of pharmacy. It is widely used as an antioxidant, anti-inflammatory, and antitumor agent. The compound can also be used as a dye intermediate.Method:2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-benzopyran-4-one can be prepared by chemical synthesis. A commonly used synthesis method is to obtain the corresponding product through the reaction of 3,4-dimethoxybenzyl alcohol and 1,3-dioxopentane, and then through reduction, acidification and other steps, the target product is finally obtained.Safety Information:The safety information of 2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-benzopyran-4-one is rarely reported. But depending on the nature and structure of similar compounds, it may be irritating and toxic. Appropriate laboratory safety measures should be taken during use and contact with skin, eyes, and respiratory tract should be avoided.

Application
2-(3,4-Dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one, also known as 3‑Hydroxy‑3',4'‑dimethoxyflavone (HDMF), is a synthetic flavonol valued for its multi-targeted anticancer properties. In glioblastoma multiforme (GBM) models, HDMF suppresses tumor cell invasion and migration by inhibiting p38 and ERK signaling, reducing matrix metalloproteinase activity, and lowering glioma stem cell markers Musashi, Sox‑2, and c‑myc. It triggers apoptosis in human leukemia cells via caspase activation, ROS generation, and JNK/SAPK signaling. The compound also inhibits Bcl‑w‑induced neurosphere formation and may block the breast cancer resistance protein (BCRP/ABCG2), sensitizing multidrug‑resistant tumors to chemotherapy. Beyond oncology, HDMF functions as an antioxidant, anti‑inflammatory agent, and dye intermediate. It is strictly intended for research use and serves as a valuable tool in drug discovery, biochemical assays, and process development. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high‑purity flavonol, scaled from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.