(S)-(-)-2-HYDROXY-N-METHYLSUCCINIMIDE(CAS#104612-35-3)

Introduction

(3S)-3-hydroxy-1-methylpyrrolidine-2,5-dione is an organic compound. IT IS KNOWN AS (S)-(-)-2-HYDROXY-N-METHYLSUCCINIMIDE WITH CAS NUMBER 104612-35-3.Quality:(3S)-3-hydroxy-1-methylpyrrolidine-2,5-dione is a solid, white crystalline powder at room temperature. It is slightly soluble in water and soluble in organic solvents such as methanol and dimethylformamide.Use:(3S)-3-hydroxy-1-methylpyrrolidine-2,5-dione is often used as a catalyst or reaction intermediate in organic synthesis. It can be used in reactions such as esterification, alkylation, guard group removal, and hydroxyl protection.Method:There are many synthesis methods of (3S)-3-hydroxy-1-methylpyrrolidine-2,5-dione, and a common method is obtained by the reaction of (3S)-3-hydroxypyrrolidine-2,5-dione with magnesium iodide.Safety Information:The safety of (3S)-3-hydroxy-1-methylpyrrolidine-2,5-dione is high, but protective measures should still be taken. Avoid inhaling aerosols or contact with skin and eyes during use, and wear protective glasses, gloves and protective clothing. In case of accidental contact, rinse immediately with plenty of water. It should be stored in a dry, well-ventilated place, away from fire sources and oxidants.

Application

(S)-(-)-2-Hydroxy-N-methylsuccinimide (CAS 104612-35-3), also known as (S)-3-hydroxy-1-methylpyrrolidine-2,5-dione, is a chiral hydroxysuccinimide derivative. This compound is the primary human metabolite of the widely used industrial solvent N-methyl-2-pyrrolidone (NMP). As a certified biomarker and analytical reference standard, it is essential for biological monitoring (biomonitoring) of NMP exposure via HPLC-MS/MS and GC-MS methods in occupational health and environmental safety studies. Beyond its role in exposure assessment, this versatile chiral building block serves as a valuable pharmaceutical intermediate and advanced organic synthesis reagent. Its rigid succinimide core with a stereogenic center is used in the asymmetric synthesis of active pharmaceutical ingredients (APIs), chiral ligands, enzyme inhibitors, and agrochemicals. It also serves as a key reference material for impurity profiling, method validation (AMV), quality control (QC) in ANDA filings, and proteomics research for studying enzyme-substrate interactions. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity (S)-(-)-2-Hydroxy-N-methylsuccinimide with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.