5-Hexyn-1-ol（CAS# 928-90-5)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29052900 |
| Packing Group | III |
Introduction
5-Hexyn-1-ol. The following is an introduction to the properties, uses, preparation methods and safety information of 5-hexyn-1-ol:
Quality:
- Appearance: Colorless liquid
- Solubility: soluble in alcohols and ether solvents, insoluble in water
Use:
- 5-Hexyn-1-ol can be used as a starting material for some organic synthesis and for the preparation of other compounds.
- In chemistry laboratories, it can be used as a solvent and catalyst in reaction processes.
Method:
The preparation method of 5-hexyn-1-ol comprises the following steps:
1. 1,5-Hexanediol is reacted with hydrogen bromide under alkaline conditions to produce the corresponding 1,5-hexanedibromide.
2. In a solvent such as acetonitrile, it reacts with sodium acetylene to form 5-hexyn-1-ol.
3. Through the appropriate separation and purification steps, a pure product is obtained.
Safety Information:
- 5-Hexyn-1-ol has a pungent odor and should be avoided by inhaling or touching the skin and eyes during handling.
- It is a flammable liquid and should be kept away from open flames and ignition sources.
- Wear protective eyewear, gloves, and laboratory goggles when using to ensure that you operate in a well-ventilated environment.
- Waste should be disposed of in accordance with local regulations.
Application
5-Hexyn-1-ol (CAS 928-90-5) is a versatile, high-purity bifunctional building block that combines a terminal alkyne with a primary alcohol. This unique structure enables its use as a critical intermediate in organic synthesis, pharmaceutical research, and material science.
In pharmaceutical R&D, it serves as a key intermediate for synthesizing complex natural products, including the Lycopodium alkaloids (+)-nankakurine A and (+)-nankakurine B. It is also a valuable PROTAC linker, enabling the construction of heterobifunctional molecules for targeted protein degradation in drug discovery.
As a specialty monomer in polymer chemistry, its reactive alkyne group allows for the creation of functionalized polymers with tailored properties for advanced coatings and materials. The terminal alkyne is a versatile handle for click chemistry and bioconjugation, facilitating the attachment of biomolecules in drug delivery systems.
Its distinct odor profile also makes it a candidate for the flavor and fragrance industry. Xinchem offers custom synthesis and contract manufacturing of high-purity 5-Hexyn-1-ol, with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
