5-methyl-2-nitrobenzoic acid(CAS#3113-72-2)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29163990 |
Introduction
5-Methyl-2-nitrobenzoic acid, also known as methylnitrobenzoic acid or p-methyl-2-nitrobenzoic acid, is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- Appearance: 5-Methyl-2-nitrobenzoic acid is a colorless to pale yellow solid.- Solubility: It is insoluble in water but soluble in organic solvents such as ethanol and ethers.- Stability: It is a relatively stable compound, but it can decompose under light conditions.- Ignition point and explosiveness: The compound is flammable and can burn or explode when exposed to heat or ignition sources.Use:- 5-Methyl-2-nitrobenzoic acid is often used as an intermediate in organic synthesis for the synthesis of other organic compounds.Method:- 5-Methyl-2-nitrobenzoic acid can be prepared by nitrification of p-toluene. Toluene is reacted with nitric acid, and then the resulting product is acidified with dilute sulfuric acid to obtain the target product.Safety Information:- 5-Methyl-2-nitrobenzoic acid is an organic compound with some toxicity. Follow relevant safety protocols such as wearing protective glasses, gloves and lab coats, and ensure that it is operated in a well-ventilated environment.- The compound should be kept away from ignition and combustibles and stored in an airtight container to prevent contact with oxygen in the air.- We will comply with relevant environmental laws and regulations and properly dispose of or recycle waste.
Application
5-Methyl-2-nitrobenzoic acid (2-Nitro-5-methylbenzoic acid, CAS 3113-72-2) is a highly versatile nitro-substituted aromatic building block widely utilized as a key intermediate in pharmaceutical, agrochemical, and material science research. As a crucial pharmaceutical intermediate, it serves as a precursor in the synthesis of anti-inflammatory, analgesic, and antimicrobial drug candidates, where the carboxylic acid group facilitates amide coupling while the nitro group can be selectively reduced to an amine for further diversification. In agrochemical chemistry, it is employed as a core scaffold for the preparation of selective herbicides and fungicides with enhanced crop protection profiles. The compound also plays an essential role in the production of high-performance dyes, pigments, and fluorescent labels for bioimaging applications. Its unique substitution pattern supports diverse transformations including reduction, esterification, and nucleophilic aromatic substitution, enabling rapid generation of substituted anilines and heterocyclic scaffolds for structure‑activity relationship (SAR) studies and library construction. Additionally, this intermediate is utilized as a sulfonylation reagent in drug discovery and as a certified reference standard for analytical method development (AMD), method validation (AMV), quality control (QC), and impurity profiling in pharmaceutical manufacturing and ANDA filings. Xinchem offers flexible custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity 5-methyl-2-nitrobenzoic acid with reliable global supply, scaling seamlessly from R&D grams to commercial metric tons. Contact us for a competitive quote.
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