6-bromo-1,2,3,4-tetrahydroisoquinoline(CAS#226942-29-6)
Introduction
6-bromo-1,2,3,4-tetrahydroisoquinoline is an organic compound with the chemical formula C9H10BrN. It is a tetrahydroisoquinoline molecule with a bromine substituent. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 6-bromo-1,2,3,4-tetrahydroisoquinoline is usually a white to light yellow solid.
-Solubility: It is soluble in common organic solvents.
-Melting point: The melting point of 6-bromo-1,2,3,4-tetrahydroisoquinoline is about 110-112 ° C.
-Density: Its density is about 1.33g/cm³.
Use:
-Intermediate: 6-bromo-1,2,3,4-tetrahydroisoquinoline can be used as an intermediate for the synthesis of other organic compounds, such as drugs, dyes and pesticides.
-Scientific research: It can also be used in chemical laboratories for various organic synthesis experiments and research.
Method:
The preparation of 6-bromo-1,2,3,4-tetrahydroisoquinoline can be obtained by reacting tetrahydroisoquinoline with cuprous bromide (CuBr) in an appropriate solvent.
Safety Information:
-6-bromo-1,2,3,4-tetrahydroisoquinoline can cause irritation to the eyes, skin and respiratory system, so wear protective glasses, gloves and a protective mask when handling.
-It should be stored in a closed container, away from fire and oxidizing agents.
-Avoid exposure to high temperatures and open flames to prevent them from burning or exploding.
-During use and storage, please follow the correct laboratory safety procedures.
Application
6-Bromo-1,2,3,4-tetrahydroisoquinoline (CAS 226942-29-6) is a functionalized tetrahydroisoquinoline (THIQ) derivative bearing a bromine atom at the 6-position. This versatile heterocyclic building block is widely used in medicinal chemistry and drug discovery, particularly for the synthesis of central nervous system (CNS) agents, including antipsychotics, antidepressants, and orexin receptor antagonists. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for introducing diverse aryl, heteroaryl, or alkyl substituents, facilitating rapid structure-activity relationship (SAR) studies. As a privileged scaffold in drug design, it also serves as a key intermediate for developing kinase inhibitors targeting cancer, inflammation, and neurodegenerative diseases. Its rigid, saturated THIQ core offers improved metabolic stability and blood-brain barrier penetration. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key pharmaceutical intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
