ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE(CAS#104776-70-7)
Introduction
The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE IS A SOLID WITH WHITE CRYSTALS AT ROOM TEMPERATURE. It has a special fragrance and is soluble in some organic solvents such as chloroform and alcohol.Use:ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE IS MAINLY USED IN ORGANIC SYNTHESIS. Some other possible applications include the use of chemical reagents, catalysts, or ligands in certain reactions.Method:THE PREPARATION METHOD OF ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE IS GENERALLY TO AMIDATION REACTION UNDER ALKALINE CONDITIONS BY REACTING ETHYL PHENYLACETATE AND ACETYLACETONE. The specific synthesis method can be adapted and optimized according to specific needs.Safety Information:THE SAFETY OF ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE HAS NOT BEEN FULLY STUDIED AND EVALUATED. As an organic compound, in general it may have certain potential risks to the human body and the environment. Proper laboratory safety operating protocols should be followed when using and handling, including wearing appropriate protective equipment, adequate ventilation, and proper disposal of waste. If necessary, consult a chemical expert or consult the relevant safety data sheet.
Application
Ethyl 5-acetylisoxazole-3-carboxylate (CAS 104776-70-7) is a functionalized heterocyclic building block containing both an acetyl and an ester group on an isoxazole ring. This structural motif is a privileged scaffold widely used as a key intermediate in medicinal chemistry and drug discovery. In pharmaceutical R&D, this compound is employed to synthesize novel small molecule libraries targeting inflammatory diseases, various cancers, and microbial infections, with its derivatives demonstrating promising anti-inflammatory, anticancer, and antimicrobial activities in preclinical studies. In addition, the acetyl group enables further condensation and heterocycle formation, while the ethyl ester allows hydrolysis to the corresponding carboxylic acid for amide coupling, facilitating rapid structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening, hit-to-lead optimization, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential research intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
