FMOC-L-Arginine（CAS# 91000-69-0)

Introduction

FMOC-L-arginine is a chemical synthesis reagent with the structural formula FMOC-L-Arg-OH. FMOC stands for 9-fluorenylmethyloxycarbonyl and L stands for a left-handed stereoisomer.

FMOC-L-arginine is an important amino acid derivative with some special properties and uses. The following is an introduction to some of the properties, uses, preparation methods and safety information of FMOC-L-arginine:

Quality:

Appearance: colorless solid;

Solubility: soluble in some organic solvents (such as dimethyl sulfoxide, dichloromethane, etc.).

Use:

Biochemical research: FMOC-L-arginine, as an amino acid compound, is commonly used in the synthesis of peptides and proteins;

Protein modification: The introduction of FMOC-L-arginine can alter the solubility, stability, and activity of proteins.

Method:

FMOC-L-arginine can be prepared by synthetic chemistry, usually by reacting the FMOC protecting group with L-arginine.

Safety Information:

The use of FMOC-L-arginine is subject to certain safe operating practices, including:

Avoid inhaling dust, contact with skin and eyes;

Wear appropriate personal protective equipment (PPE) such as lab gloves and safety glasses when in use;

Comply with laboratory waste disposal regulations and dispose of waste properly.

Application

Fmoc-L-Arginine (Fmoc-Arg-OH, CAS 91000-69-0) is a high-purity, Nα-Fmoc-protected form of the essential amino acid L-Arginine. It is a fundamental building block and critical raw material for both solid-phase and solution-phase peptide synthesis (SPPS). The base-labile Fmoc (9-fluorenylmethyloxycarbonyl) protecting group enables efficient and selective deprotection under mild conditions, facilitating the stepwise assembly of complex peptide chains without compromising the integrity of the acid-labile side-chain protecting groups or the growing peptide.

This compound is indispensable for incorporating arginine residues into a wide range of peptides, which play crucial roles in numerous biological processes. Its applications are central to several key areas of pharmaceutical and biochemical research:

• Drug Discovery and Development: Fmoc-L-Arginine drives the synthesis of peptide-based therapeutics and peptidomimetics. The presence of arginine residues is vital for enhancing the targeting and binding affinity of drug candidates, leading to next-generation therapeutics with improved specificity and reduced side effects. It is particularly valuable for creating cell-penetrating peptides (CPPs), which are crucial for intracellular drug delivery.
• Protein Engineering: It is used to create peptides for structural and functional studies, enabling researchers to investigate protein-protein interactions and construct complex peptide scaffolds.
• Biochemical Research: As a stable, protected amino acid, it bridges gaps in complex peptide assembly, making it a versatile tool for a wide array of synthetic applications, from creating peptide libraries to studying biological pathways.

Fmoc-L-Arginine is typically supplied as a white to off-white crystalline powder with high purity (≥95.0% to ≥99.99%). It is characterized by a melting point of 145-150°C and a specific optical rotation of approximately +9.0° (c=1% in DMF). For long-term stability, it should be stored at 2-8°C, protected from moisture and air. Xinchem offers custom synthesis and reliable contract manufacturing of this high-purity Fmoc amino acid to support your peptide-based drug discovery and development programs. Contact us for a competitive quote and dependable global supply.