Isopropylamine (CAS 75-31-0), also known as 2-aminopropane, monoisopropylamine or MIPA, is the smallest secondary-branched primary amine: a colourless, volatile liquid with an ammonia-like odour, the molecular formula C₃H₉N, a molecular weight of 59.11 g/mol, a boiling point of approximately 32–33 °C, a flash point of −37 °C and complete miscibility with water and most organic solvents. Its commercial identity rests on a combination of properties that make it both exceptionally useful and exceptionally demanding to handle: the isopropyl group provides steric bulk and lipophilicity that its linear isomer n-propylamine lacks, while the primary amine function remains highly reactive toward acids, isocyanates, epoxides and carbonyl compounds. That reactivity profile has made isopropylamine the salt-forming partner of choice for glyphosate—the isopropylamine salt is one of the most widely used glyphosate formulations globally—and a critical intermediate for atrazine, bentazone, rubber vulcanisation accelerators, surfactants, corrosion inhibitors and pharmaceutical actives including propranolol. The market reflects that breadth and a supply base that is structurally weighted toward Asia. The global isopropylamine market is forecast to grow by USD 129.3 million during 2025–2030 at a 6.0% CAGR, driven by escalating agrochemical demand, pharmaceutical expansion and industrialisation in APAC. Alternative scopes place the 2025 market at USD 1.71 billion, rising to USD 2.36 billion by 2034 at a 3.64% CAGR. The qualifying question for buyers is therefore not “what does a tonne of isopropylamine cost” but “which grade, water and impurity profile, and dangerous-goods documentation package does my glyphosate-salt, rubber or pharmaceutical application actually require.”
Core Application Fields and Demand Architecture
Isopropylamine demand concentrates in four functional arenas where its branched C3 structure and primary-amine reactivity deliver performance that linear amines and ammonia cannot replicate at equivalent selectivity or formulation stability: agrochemical salt formation and herbicide synthesis, rubber chemicals and polymer additives, pharmaceutical and organic synthesis, and surfactants, corrosion inhibitors and water treatment.
In agrochemical salt formation and herbicide synthesis, isopropylamine is the largest single demand driver. The glyphosate isopropylamine salt is the dominant salt form in many agricultural markets, valued for its solubility, formulation stability and crop safety relative to other glyphosate salts. Isopropylamine is also a key intermediate for atrazine and bentazone, and the agrochemical sector accounts for roughly 42% of consumption in the fatty-amine-adjacent application scope. The specification logic here is stringent: water content must be controlled because water competes with the acid-base salt formation and can shift the stoichiometry; colour and trace impurities must be low because they carry through to the formulated herbicide and affect storage stability and appearance. A lot that carries excess water or a colour body can produce a glyphosate salt that fails the formulator’s specification, and the problem is discovered after the batch is blended.
In rubber chemicals and polymer additives, isopropylamine functions as an intermediate for rubber vulcanisation accelerators and as a regulator or stabiliser in polymer processing. It is used in the synthesis of thiuram and dithiocarbamate accelerators, where its branched structure influences cure kinetics and scorch safety. The specification logic is purity and reactivity: a lot with residual ammonia or a secondary amine impurity can shift the accelerator’s activity and alter the cure profile, and the rubber compounder discovers the deviation in the rheometer, not in incoming QC.
In pharmaceutical and organic synthesis, isopropylamine serves as a building block for active pharmaceutical ingredients including propranolol and other beta-blockers and cardiovascular drugs, as well as for dyes, photographic chemicals and specialty intermediates. The pharmaceutical sector accounts for approximately 18% of demand. The specification logic here is the most demanding: water, ammonia and organic impurities must be controlled to pharmaceutical-grade limits, and the lot must be supported by documentation that satisfies ICH Q3C residual-solvent requirements and, where applicable, pharmacopoeial-grade qualification. A lot that carries a secondary amine impurity can introduce a regioisomeric by-product into a multi-step API synthesis, and the medicinal chemist discovers the problem after the coupling step.
In surfactants, corrosion inhibitors and water treatment, isopropylamine is used to synthesise isopropylamine-based surfactants, corrosion inhibitors for oilfield and industrial systems, and water-treatment chemicals. These applications are smaller in volume than agrochemicals but value the same attributes: consistent amine content, low colour and predictable reactivity with the electrophile being used to build the surfactant or inhibitor.
Regulatory Profile: Not an SVHC, Not Annex XIV, but a Class 3(8) PG I Dangerous Good with Severe Acute Toxicity and Corrosivity
Isopropylamine is not on the REACH Candidate List (SVHC) and not on Annex XIV. It is, however, not a “light-documentation” amine: it carries a harmonised CLP classification that reflects severe acute toxicity by all three routes, flammability and corrosivity, and it is regulated as a Class 3(8), Packing Group I dangerous good for transport. That combination makes packaging, logistics and industrial-hygiene documentation part of the product, not an administrative afterthought.
The CLP classification is the central fact for handling. Isopropylamine is Flam. Liq. 1 (H224, extremely flammable liquid and vapour), Acute Tox. 3 by oral, dermal and inhalation routes (H301, H311, H331), Skin Irrit. 2 (H315), Eye Irrit. 2 (H319) and STOT SE 3 (H335, respiratory irritation). The signal word is Danger, and the SDS additionally notes that the product should be regarded as skin corrosive category 1A–1C based on the supplier’s data. The practical consequence is that isopropylamine requires engineering controls, respiratory protection, eye/face protection and chemical-resistant gloves in any industrial setting, and that the supplier’s SDS and exposure-scenario documentation are part of the product’s fitness for use.
The REACH position is favourable in one respect and requires care in another. Isopropylamine is registered under REACH with registration number 01-2119463274-39. It is not on the Candidate List, not on Annex XIV and not subject to Annex XVII restriction for its industrial uses. That means its market access is not blocked by an authorisation requirement, which is a materially simpler position than that of many chlorinated or reprotoxic solvents reviewed in this series. The documentation burden instead comes from the acute-toxicity and corrosivity classification, and from the transport regime.
The occupational exposure limits are jurisdiction-specific and operationally decisive. In the EU, France has established a VLEP of 5 ppm (12 mg/m³) for isopropylamine, and other member states apply comparable national limits. In the U.S., ACGIH recommends a TLV-TWA of 5 ppm with a STEL of 10 ppm, and NIOSH has established a REL of 5 ppm (12 mg/m³) as a TWA with a ceiling of 10 ppm. For Russia and the EAEU, imported material must be accompanied by a Russian-language SDS that states the applicable working-area limit and the required ventilation and PPE measures.
The transport classification is the most logistically consequential fact. Isopropylamine is UN 1221, Class 3 (flammable liquid) with subsidiary hazard 8 (corrosive), Packing Group I. The PG I designation—the highest danger level—reflects the combination of an extremely low flash point (−37 °C) and corrosive/acute-toxic properties, and it means that the material cannot move through standard channels without dangerous-goods paperwork, specialised packaging and segregation from incompatible materials. For Russian and EAEU buyers, the shipment must carry UN 1221 documentation, and the packaging must be verifiable as compliant before release.
Global Supply Structure and Manufacturer Differentiation
Global isopropylamine supply is structurally weighted toward Asia and moderately concentrated at the merchant-market level. The producer landscape identified in market reporting includes BASF, Eastman, US Amines Limited, Alkyl Amines Chemicals Limited, OQ Chemicals GmbH, Arkema, Mitsubishi Chemical and Zhejiang Xinhua Chemical, alongside Chinese producers such as Nanjing Qinfu Chemical and Anhui Haoyuan Chemical. Global capacity is highly concentrated in North America, Europe and Asia-Pacific, which together account for more than 85% of installed capacity, and China is both the largest producer and a net exporter, with exports reaching 29,000 tonnes in 2025. Recent export controls on agricultural chemicals to secure domestic supply for spring planting have temporarily narrowed Chinese export channels, extending lead times and raising freight costs for international buyers.
Differentiation operates on three axes that matter more to a glyphosate formulator or a pharmaceutical process chemist than the headline assay. The first is water and ammonia control. Isopropylamine is hygroscopic and volatile, and residual water or ammonia affects salt-formation stoichiometry, rubber-accelerator cure kinetics and pharmaceutical coupling yields. A supplier that controls water and ammonia within narrow limits and documents them lot by lot reduces the downstream burden of re-assay and re-optimisation. The second axis is grade breadth and documentation depth. The market segments into 70% purity and 99% purity grades, with the 99% grade serving pharmaceutical and high-performance rubber applications and the 70% grade serving cost-sensitive agrochemical and industrial uses. A supplier that can offer both grades from a consistent production and analytical platform, with a certificate of analysis that reports purity, water and ammonia against the agreed specification, allows a customer to scale across applications without re-qualifying a new source. The third axis is dangerous-goods logistics and language support. The UN 1221, Class 3(8), PG I classification means that packaging and transport documentation are part of the product, and a supplier that can arrange compliant PG I logistics to Russia and the EAEU with Russian-language SDS and UN 1221 documentation reduces the buyer’s clearance and qualification burden.
For Russian and EAEU buyers, the supply structure creates a specific dependency shaped by the transport regime and by the export-control environment. Isopropylamine is imported rather than domestically produced at merchant scale, and the PG I, Class 3(8) classification makes logistics the binding constraint: not every freight forwarder can handle a corrosive flammable liquid at the highest packing group. Chinese export controls on agricultural chemicals add a layer of uncertainty to lead times, which means that buyers who rely on isopropylamine for glyphosate-salt or atrazine production need a supplier with safety stock and alternative logistics corridors, not just a competitive price. XINCHEM positions its isopropylamine supply around this requirement, combining 70% and 99% grades with lot-specific water and ammonia data, Russian-language SDS, and UN 1221 PG I logistics support, so that Russian and EAEU buyers can qualify imported material without reconstructing the compliance case internally.
Regional Demand Dynamics
Isopropylamine demand follows the geography of glyphosate and atrazine formulation, rubber and tyre production, and pharmaceutical API manufacturing rather than the geography of propylene or ammonia feedstock.
Asia-Pacific is the largest and most dynamic region, driven by escalating agrochemical demand, robust pharmaceutical expansion and accelerated industrialisation. China is the largest producer and a net exporter, and its domestic demand is anchored in glyphosate isopropylamine salt, atrazine and rubber chemicals. India is a significant and growing market, supported by generic pesticide and pharmaceutical manufacturing, and its Alkyl Amines Chemicals position reflects the region’s role as both a producer and a consumer. The region’s demand is volume-led and increasingly documentation-sensitive, because export-oriented agrochemical and pharmaceutical manufacturers must satisfy destination-market requirements even where the local regime is less prescriptive.
North America is a mature, specification-intensive market. Demand is anchored in glyphosate and atrazine formulation, rubber accelerators for tyre and industrial rubber production, and pharmaceutical synthesis, with a strong industrial-hygiene and process-safety culture that places a premium on SDS quality, exposure-scenario documentation and PG I logistics discipline. Europe is similarly mature, with demand concentrated in agrochemicals, rubber chemicals and pharmaceutical intermediates, and with a regulatory culture that requires clear REACH registration status and occupational-exposure documentation.
Russia and the EAEU form an import-dependent contour with a specific logistics constraint. Isopropylamine is supplied for glyphosate-salt and atrazine production, rubber chemicals and a smaller pharmaceutical segment, and there is no large-scale domestic merchant production. The UN 1221, Class 3(8), PG I classification means that the buyer must qualify not only the product but the logistics chain, and the recent narrowing of Chinese agricultural-chemical export channels adds lead-time risk. XINCHEM addresses this contour by maintaining Russian-language SDS and UN 1221 documentation and by structuring supply schedules to buffer the export-control and freight variability that affects PG I materials.
Future Outlook and Strategic Imperatives
The isopropylamine market will grow at a mid-single-digit rate—6.0% CAGR by value through 2030 in the base case, or 3.64% to 2034 in the broader scope—but the quality of that growth is shaped by three structural forces that reward documentation depth and logistics capability over commodity price competition.
First, agrochemical demand will remain the volume anchor and the most regulation-sensitive segment. Glyphosate isopropylamine salt and atrazine are mature products, but their demand is sensitive to regulatory decisions in destination markets and to export-control policies in producing countries. Suppliers that can hold consistent water and impurity specifications across lots, and that can support the formulator’s own regulatory filings, will be preferred over those offering a price-led spot lot. Second, the PG I transport regime will remain the binding logistics constraint. Isopropylamine cannot be shipped like a Class 3 PG III solvent; it requires specialised packaging, segregation and dangerous-goods documentation, and a supplier that cannot execute PG I logistics cannot serve the market regardless of its production capability. Third, pharmaceutical and high-purity grades will command a growing share of value. The 99% grade is the entry point for pharmaceutical and high-performance rubber applications, and the growth of generic API manufacturing in Asia is pulling demand for material with tighter water, ammonia and colour specifications.
For Russian and EAEU buyers, the strategic implication is that isopropylamine procurement should be treated as a grade-and-logistics partnership rather than a price comparison. A lot that carries water or ammonia above the glyphosate-salt or rubber-accelerator specification does not simply cost the price of the drum; it can shift salt stoichiometry, alter cure kinetics or introduce an impurity into a pharmaceutical synthesis. A shipment that lacks UN 1221 PG I documentation or a Russian-language SDS can be held at customs or rejected at the plant gate. The lowest-risk supplier is the one that can match the grade to the application, document water and ammonia lot by lot, and support the buyer with Russian-language documentation and proven PG I dangerous-goods logistics—the position XINCHEM occupies for isopropylamine in the Russian and EAEU market.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals, Shanghai XinChem Co., Ltd. (XinChem) offers isopropylamine (CAS 75-31-0) in 70% and 99% purity grades, serving glyphosate-salt and atrazine formulators, rubber accelerator and polymer additive producers, pharmaceutical API manufacturers, and surfactant and corrosion-inhibitor customers. Our isopropylamine is supplied with controlled water and ammonia content, lot-specific certificate-of-analysis data, and the documentation support—including Russian-language SDS and UN 1221 Class 3(8), PG I transport documentation—that grade-specific qualification and dangerous-goods logistics require.
Technical and Quality Advantages
Grade-Specific Water and Ammonia Control: Isopropylamine is supplied against the 70% and 99% purity specification windows, with water and ammonia controlled to the limits relevant to the intended use. In glyphosate-salt formation, water competes with the acid-base reaction; in rubber accelerators, residual ammonia shifts cure kinetics; in pharmaceutical synthesis, a secondary amine impurity can introduce a regioisomeric by-product. Lot-level data is the specification that determines whether the lot can enter a validated agrochemical or API process, not just a general-purpose amine application.
Dangerous-Goods Logistics Capability: The UN 1221, Class 3(8), PG I classification makes logistics a product attribute. XinChem arranges PG I-compliant packaging, segregation and documentation for Russia and EAEU destinations, with Russian-language SDS and certificate-of-analysis support, reducing the clearance and handling risk that a general-purpose forwarder cannot manage.
Lot-Specific Certificate of Analysis: Each lot is supported by a certificate of analysis reporting assay, water, ammonia and colour against the agreed specification. For agrochemical and pharmaceutical customers, this documentation is the basis for incoming qualification and for demonstrating conformance to the formulator’s or API manufacturer’s specification.
Supply Reliability and Export-Control Awareness: XinChem structures supply schedules to buffer the export-control and freight variability that affects Chinese-origin PG I amines, so that buyers are not exposed solely to spot-market lead-time shocks. Both the 70% and 99% grades are supplied from a consistent production and analytical platform, allowing customers to scale across applications without re-qualifying a new source.
Packaging and Logistics Flexibility
Isopropylamine is available in ISO tanks, drums and IBCs appropriate for a PG I, Class 3(8) dangerous good, with sealed containers for pilot and laboratory qualification. For Russia and EAEU destinations, XinChem arranges PG I logistics with UN 1221 documentation, Russian-language SDS and certificate-of-analysis support, reducing clearance friction for a material that cannot move through standard channels without specialised dangerous-goods handling.
Application Support and Supply Reliability
XinChem’s technical team assists with grade selection for glyphosate isopropylamine salt, atrazine and bentazone synthesis, rubber vulcanisation accelerators, propranolol and other API intermediates, and surfactant and corrosion-inhibitor applications, and with the water, ammonia and PG I documentation requirements that agrochemical and pharmaceutical qualification demands. Supply schedules accommodate both qualification orders and contract volumes, with stock and logistics planning aligned to the propylene and ammonia feedstock dynamics and the export-control environment that shapes isopropylamine availability.
Why Choose XinChem
Expertise: Deep experience in short-chain amines and amine-derived intermediates, with application knowledge spanning agrochemical salt formation, rubber chemicals, pharmaceutical synthesis and surfactant chemistry.
Consistency: Control of water, ammonia and purity against grade-specific specifications—the parameters that determine whether isopropylamine forms a stable glyphosate salt or shifts a cure profile, and whether a pharmaceutical coupling delivers the intended API or a regioisomeric impurity.
Compliance Readiness: Documentation structured around the H224, H301/H311/H331, H315, H319 and H335 classification, the non-SVHC, non-Annex XIV REACH status, the applicable occupational exposure limits, and the UN 1221 Class 3(8), PG I transport regime, with Russian-language SDS support.
Responsiveness: Direct technical and commercial access, with order structures from qualification volumes to ISO tank and contract supply.
Contact us now to discuss your isopropylamine requirements and request a specification sheet or qualification sample.
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Nov-12-2026