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4-Chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6), also known as 2-chloro-5-(trifluoromethyl)phenol, 3-hydroxy-4-chlorobenzotrifluoride, or 6-chloro-α,α,α-trifluoro-m-cresol, is a halogenated phenolic compound with the molecular formula C₇H₄ClF₃O and a molecular weight of 196.55 g/mol. Its molecular structure combines a phenolic hydroxyl group (-OH), a chlorine atom, and a trifluoromethyl group (-CF₃) on a single benzene ring, creating a dual-functional building block with orthogonal reactive handles. The compound typically appears as a colorless to pale yellow clear liquid with a density of 1.459 g/mL at 25°C, a boiling point of 87–88°C at 38 mmHg, a refractive index of n20D 1.47, and a flash point of 46°C. It is soluble in organic solvents such as ether and alcohols but has low solubility in water. The compound is typically supplied at ≥96% to ≥98% purity (GC) and should be stored at 2–8°C in a tightly sealed container protected from light and moisture.

4-Chloro-3-hydroxybenzotrifluoride is a strategically important dual-functional fluorinated phenol building block that serves as a key synthetic intermediate in agrochemical discovery, pharmaceutical R&D, and advanced materials science. Its unique combination of a phenolic hydroxyl group—enabling etherification and esterification—and a chloro substituent—amenable to cross-coupling reactions—confers exceptional versatility for constructing complex molecular architectures. The electron-withdrawing trifluoromethyl group enhances lipophilicity, metabolic stability, and biological activity of downstream derivatives, making this compound an indispensable building block in modern medicinal and agrochemical chemistry. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regulatory landscape, and future outlook of this strategically important fluorinated phenolic intermediate.

Core Application Fields and Demand

Market demand for 4-chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) is concentrated in four primary sectors: agrochemical development and pesticide manufacturing (approximately 45–50% of global consumption), pharmaceutical synthesis and API manufacturing (approximately 25–30%), advanced materials and specialty coatings (approximately 15–20%), and analytical chemistry and research applications (approximately 5–10%). Its dual-functional reactivity and the unique electronic properties conferred by the trifluoromethyl group serve as the core drivers of sustained demand growth.

In agrochemical development and pesticide manufacturing, 4-chloro-3-hydroxybenzotrifluoride is a fundamental scaffold for developing novel herbicides, pesticides, and fungicides. The compound is widely utilized in research focused on pesticide formulation, providing effective control over various agricultural pests while minimizing environmental impact. The trifluoromethyl group often enhances biological activity and metabolic stability of the resulting agrochemical active ingredients. The phenolic hydroxyl group provides a handle for further functionalization via etherification or esterification, enabling the construction of diverse herbicidal and fungicidal structures. The chloro group is amenable to cross-coupling reactions, allowing rapid diversification of molecular architectures for structure-activity relationship (SAR) studies. The compound is also used as a stabilizer in the fields of plastics, rubber, dyes, and coatings due to its molecular structure containing hydroxyl groups and fluorine atoms, which impart good stability and antioxidant properties.

In pharmaceutical synthesis and API manufacturing, 4-chloro-3-hydroxybenzotrifluoride serves as a critical precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting enzyme inhibition and receptor modulation. The compound is employed as an intermediate in the synthesis of pharmaceutical compounds, contributing to the creation of drugs that target specific health conditions. The trifluoromethyl group is a privileged structural motif in medicinal chemistry, widely used to improve metabolic stability, lipophilicity, and bioavailability of drug candidates. The phenolic hydroxyl group enables the formation of ethers and esters, while the chloro substituent provides a site for palladium-catalyzed cross-coupling reactions to introduce diverse aryl and heteroaryl groups.

In advanced materials and specialty coatings, 4-chloro-3-hydroxybenzotrifluoride is applied in the formulation of advanced materials, enhancing properties such as thermal stability and chemical resistance in coatings and plastics. The compound is used as a reagent in organic synthesis, for example, for the synthesis of fluorinated compounds. Its fluorine content contributes to increased thermal stability, chemical resistance, and hydrophobicity of the resulting materials, making it valuable in the development of high-performance coatings, adhesives, and functional polymers.

In analytical chemistry and research applications, 4-chloro-3-hydroxybenzotrifluoride is utilized as a reagent in various analytical techniques, aiding in the detection and quantification of other compounds in complex mixtures. The compound serves as a valuable tool in academic and industrial research, facilitating studies in organic chemistry and the development of new chemical processes.

Key Properties and Reactivity Profile

4-Chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) is a dual-functional fluorinated phenol whose value derives from the orthogonal reactivity of its hydroxyl, chloro, and trifluoromethyl substituents.

Key physicochemical parameters include:

Molecular Formula: C₇H₄ClF₃O
Molecular Weight: 196.55 g/mol
CAS Number: 40889-91-6
MDL Number: MFCD00019995
Synonyms: 2-Chloro-5-(trifluoromethyl)phenol; 3-Hydroxy-4-chlorobenzotrifluoride; 6-Chloro-α,α,α-trifluoro-m-cresol
IUPAC Name: 2-chloro-5-(trifluoromethyl)phenol
Appearance: Colorless to pale yellow clear liquid (light orange to yellow to green in some grades)
Purity: ≥96% (GC); ≥98% (GC) available
Boiling Point: 87–88°C at 38 mmHg
Density: 1.459 g/mL at 25°C
Refractive Index: n20D 1.47
Flash Point: 46°C; 115°F
pKa: 7.49 ± 0.10 (predicted)
Solubility: Low solubility in water; soluble in ether, alcohols, and organic solvents
Storage: 2–8°C, sealed, protect from light and moisture
GHS Classification: Warning; H226 (Flammable liquid and vapour), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
Hazard Symbols: Xi (Irritant)
Risk Codes: R10 (Flammable), R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Description: S16 (Keep away from sources of ignition), S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice), S36/37/39 (Wear suitable protective clothing, gloves, and eye/face protection)
WGK Germany: 3 (high hazard to water)
HS Code: 29081990
Transport Classification: UN 1993 (Flammable liquids, n.o.s.), Class 3, Packing Group III

The compound’s reactivity is defined by its three orthogonal handles: the phenolic hydroxyl group enables etherification, esterification, and the formation of metal phenoxides; the chloro substituent at the 2-position activates the aromatic ring toward nucleophilic aromatic substitution and serves as a site for palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig); and the trifluoromethyl group provides strong electron-withdrawing character that modulates the electronic environment of the ring, enhances the acidity of the phenolic hydroxyl (pKa 7.49), and improves the metabolic stability of downstream derivatives. The compound exhibits good stability to light, heat, and oxygen, making it suitable for storage and handling under standard laboratory conditions.

Major Market Participants

The global supply system for 4-chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) features a pattern of “specialized fluorochemical manufacturers, multinational research chemical distributors, and Chinese producers serving distinct market segments.” As a specialized fluorinated phenolic intermediate rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to agrochemical R&D, pharmaceutical development, and materials science applications.

In the global research and high-purity segment, key international suppliers include Tokyo Chemical Industry (TCI), offering the compound at >98.0% (GC) purity under product code C2947, with a boiling point of 88°C at 38 mmHg. Sigma-Aldrich (Merck) offers the compound at 96% purity. abcr GmbH (Germany) offers the compound at 98% purity under product code AB103193 with a flash point of 46°C and packing group III classification. AK Scientific (AKSci) offers the compound at 98% purity under product code W6142. Chem-Impex International offers the compound at ≥98% (GC) purity under catalog number 46369 with a boiling point of 88°C at 38 mmHg and a density of 1.47 g/mL. Indofine Chemical Company offers the compound with pricing of $120.00 per 25 g and $295.00 per 100 g. Apollo Scientific offers the compound through CymitQuimica with purity grades of 98%. Wako Pure Chemical (Fujifilm) offers the compound under product number 002352. These suppliers serve the agrochemical, pharmaceutical, and academic research communities with products that meet rigorous quality specifications.

In the industrial and large-scale production segment, Chinese manufacturers have emerged as significant players in the global supply chain. XinChem is a reliable manufacturer and supplier of high-purity 4-chloro-3-hydroxybenzotrifluoride from China, offering the compound with stringent quality standards for use in agrochemical synthesis, pharmaceutical intermediate manufacturing, and specialty materials applications. XinChem provides the compound as a colorless to pale yellow clear liquid with comprehensive quality documentation, batch-specific Certificates of Analysis (COA), customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing. The company emphasizes that the compound has low solubility in water and can be dissolved in organic solvents such as ether and alcohols, and is relatively stable to light, heat, and oxygen. Other Chinese suppliers include Capot Chemical, offering the compound at 96% minimum purity (GC) with moisture ≤0.5% under product number 2851, with production scale up to kilograms. Bide Pharmatech offers the compound at 98% purity with batch quality inspection reports (NMR, HPLC, GC) under catalog number BD417040889-91-6. Shanghai Aladdin Biochemical Technology offers the compound under catalog number C2947 with pricing from ¥31.90 per bottle. Shanghai Hansi Chemical (上海瀚思化工) offers the compound for industrial applications. Hubei Xinliheng Chemical (鑫立恒) offers the compound at 98% purity in 1 kg packaging. Jingzhou Yinjie Chemical (荆州市尹杰化工) and Hubei Qifei Pharmaceutical & Chemical (湖北齐飞医药化工) offer the compound at 99% purity in 25 kg cardboard drums, woven bags, or plastic drums. Chinese suppliers offer the compound at various purity grades (typically 96–99%) and packaging options—from grams to multi-kilogram quantities—serving both domestic and export markets.

Regional Market Dynamics

The global 4-chloro-3-hydroxybenzotrifluoride market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the agrochemical, pharmaceutical, and materials science industries in these regions.

The Asia-Pacific region has emerged as a significant production hub for 4-chloro-3-hydroxybenzotrifluoride, with China hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing agrochemical and pharmaceutical industries. Chinese suppliers offer the compound at various purity grades (typically 96–99%) and packaging options, serving both domestic and export markets. The growing agrochemical R&D, pharmaceutical manufacturing, and specialty chemical sectors in China, India, Japan, and South Korea continue to drive regional consumption growth. The compound is classified as an organic synthesis intermediate in the Chinese market, with multiple suppliers offering the product in packaging sizes ranging from grams to 25 kg.

North America remains a key market for high-purity and research-grade 4-chloro-3-hydroxybenzotrifluoride, driven by demand from the agrochemical industry, pharmaceutical companies, and academic research institutions. The United States hosts numerous research organizations, pharmaceutical companies, and agrochemical developers that require high-quality fluorinated phenolic building blocks for drug discovery and pesticide development. Chem-Impex International, AK Scientific, and Indofine Chemical Company serve the North American market with extensive distribution networks. The region’s well-established regulatory framework, including EPA oversight of agrochemical intermediates and FDA regulations for pharmaceutical applications, supports demand for high-grade research chemicals and pharmaceutical intermediates.

Europe is characterized by stringent regulatory requirements, including REACH registration, and a strong focus on quality and sustainability in agrochemical and pharmaceutical applications. European agrochemical companies, pharmaceutical manufacturers, and research institutions demand high-purity fluorinated phenolic intermediates with comprehensive documentation. abcr GmbH (Germany) and Apollo Scientific (UK) serve the European market with in-stock availability. The compound is registered under REACH with an active registration status. The region’s advanced agrochemical and pharmaceutical industries support steady demand for high-quality fluorinated building blocks.

Japan represents a specialized market where 4-chloro-3-hydroxybenzotrifluoride is supplied by Tokyo Chemical Industry (TCI) and Wako Pure Chemical for agrochemical research, pharmaceutical development, and fine chemical applications.

Regulatory and Safety Considerations

As a flammable halogenated phenolic compound and agrochemical intermediate, 4-chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.

GHS classification and handling: 4-Chloro-3-hydroxybenzotrifluoride is classified with the signal word “Warning”. Hazard statements include H226 (Flammable liquid and vapour), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). The compound is classified as Flam. Liq. 3, Skin Irrit. 2, Eye Irrit. 2, and STOT SE 3. Precautionary statements include P210 (Keep away from heat, sparks, open flames, and hot surfaces), P233 (Keep container tightly closed), P240 (Ground and bond container and receiving equipment), P241 (Use explosion-proof electrical equipment), P242 (Use only non-sparking tools), P243 (Take action to prevent static discharges), P261 (Avoid breathing vapours), P264 (Wash skin thoroughly after handling), P271 (Use only outdoors or in a well-ventilated area), P280 (Wear protective gloves, protective clothing, eye protection, and face protection), P303+P361+P353 (IF ON SKIN: Take off immediately all contaminated clothing; rinse skin with water/shower), P304+P340 (IF INHALED: Remove person to fresh air and keep comfortable for breathing), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing), P312 (Call a POISON CENTER or doctor if you feel unwell), P332+P313 (If skin irritation occurs: Get medical advice/attention), P337+P313 (If eye irritation persists: Get medical advice/attention), P362+P364 (Take off contaminated clothing and wash it before reuse), P370+P378 (In case of fire: Use dry sand, dry chemical, or alcohol-resistant foam to extinguish), P403+P235 (Store in a well-ventilated place; keep cool), P405 (Store locked up), and P501 (Dispose of contents/container to an approved waste disposal plant). The WGK Germany classification is 3 (high hazard to water). The compound is classified as a combustible liquid (storage class 3).

Storage and stability: 4-Chloro-3-hydroxybenzotrifluoride should be stored at 2–8°C in a tightly sealed container protected from light and moisture. The compound is stable to light, heat, and oxygen under recommended storage conditions. It should be kept away from strong oxidizing agents to avoid dangerous reactions and stored in a cool, dry place away from fire and high-temperature environments.

Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements for import and use. The compound is listed on the New Zealand Inventory of Chemicals (NZIoC). Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, 4-chloro-3-hydroxybenzotrifluoride is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. For agrochemical intermediate applications, manufacturers must comply with relevant EPA regulations and quality standards. The compound is not a controlled substance, is not an antibiotic, and is not DEA-regulated.

Transport information: 4-Chloro-3-hydroxybenzotrifluoride is classified as a dangerous good for international transport under UN 1993 (Flammable liquids, n.o.s.), Hazard Class 3, Packing Group III. Proper packaging, labeling, and documentation are required for shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and IATA/ADR standards for flammable liquids. The HS code for the compound is 29081990. The compound is typically shipped at ambient temperature with appropriate protection from moisture and ignition sources. A hazmat fee may apply to certain package sizes and shipment methods.

Future Outlook

The market outlook for 4-chloro-3-hydroxybenzotrifluoride is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized fluorinated phenolic intermediate, its dual-functional reactivity and essential role in agrochemical and pharmaceutical development position it for steady growth in the coming years.

Key growth drivers include:

Expansion of agrochemical development: The growing global demand for novel herbicides, pesticides, and fungicides—driven by increasing food production needs and the development of more selective, environmentally friendly crop protection agents—supports consumption of 4-chloro-3-hydroxybenzotrifluoride as a fundamental scaffold for agrochemical active ingredients. The trifluoromethyl group enhances biological activity and metabolic stability, making the compound valuable for developing next-generation pesticides.
Growth in pharmaceutical R&D: The increasing emphasis on fluorine incorporation in drug design drives demand for versatile fluorinated building blocks. The compound serves as a critical precursor for APIs targeting enzyme inhibition and receptor modulation, supporting drug discovery programs in oncology, inflammation, and metabolic diseases.
Expansion of advanced materials and specialty coatings: The growing market for high-performance coatings, adhesives, and functional polymers with enhanced thermal stability and chemical resistance creates new opportunities for the compound as a fluorinated building block for materials science applications.
Increasing focus on structure-activity relationship (SAR) studies: The compound’s utility as a privileged building block for medicinal and agrochemical discovery supports the growing adoption of SAR studies in pharmaceutical and agrochemical R&D, enabling rapid diversification of molecular architectures.
Growth in fluorinated specialty chemicals: The expanding market for fluorinated compounds in pharmaceuticals, agrochemicals, and materials science drives demand for versatile fluorinated phenolic intermediates like 4-chloro-3-hydroxybenzotrifluoride.

Challenges and considerations:

Flammability and handling requirements: The compound’s classification as a flammable liquid (H226, UN 1993) requires specialized handling, packaging, and shipping procedures that may increase costs.
Environmental hazard: The WGK Germany classification of 3 (high hazard to water) requires responsible handling and disposal, with appropriate containment measures to prevent environmental release.
Competition from alternative fluorinated building blocks: The market faces competition from other fluorinated phenols and halogenated aromatic intermediates with similar reactivity profiles.
Limited scale: As a specialized fluorinated phenolic intermediate, the market for 4-chloro-3-hydroxybenzotrifluoride is smaller than that of commodity chemicals.
Regulatory compliance: Increasingly stringent agrochemical and pharmaceutical regulations may require ongoing investment in quality systems and documentation.

To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for agrochemical, pharmaceutical, and materials science applications will be well-positioned to capture growing demand.

Shanghai XinChem Co., Ltd. (XinChem)

As a world-leading supplier of organic chemicals and fluorinated building blocks, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the agrochemical, pharmaceutical, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 4-Chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for agrochemical companies, pharmaceutical manufacturers, and research institutions seeking this versatile dual-functional fluorinated phenol building block.

1. Technical Advantages

Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 4-chloro-3-hydroxybenzotrifluoride products. The production process incorporates established synthetic routes—including the reaction of trifluorotoluene with thionyl chloride under controlled conditions followed by hydrochlorination to obtain the target compound—enabling the delivery of products with purity ≥96% (GC) and ≥98% (GC) to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities, and batch-to-batch reproducibility, providing customers with reliable performance in agrochemical synthesis, pharmaceutical intermediate manufacturing, and specialty materials applications.

Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (GC), density, refractive index, boiling point, water content, and impurity profiles. XinChem offers batch-specific COA, customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing.

2. Product Advantages

High Purity and Consistent Quality
XinChem offers 4-chloro-3-hydroxybenzotrifluoride with purity ≥96% (GC) and ≥98% (GC) available, ensuring optimal performance in agrochemical synthesis, pharmaceutical intermediate manufacturing, and specialty materials applications. The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery, crop protection, and advanced materials. The compound is supplied as a colorless to pale yellow clear liquid with low water solubility and good solubility in organic solvents such as ether and alcohols.

Comprehensive Specifications
Key specifications include:

Molecular Formula: C₇H₄ClF₃O
Molecular Weight: 196.55 g/mol
CAS Number: 40889-91-6
MDL Number: MFCD00019995
Synonyms: 2-Chloro-5-(trifluoromethyl)phenol; 3-Hydroxy-4-chlorobenzotrifluoride; 6-Chloro-α,α,α-trifluoro-m-cresol
Appearance: Colorless to pale yellow clear liquid
Purity: ≥96% (GC) / ≥98% (GC) available
Boiling Point: 87–88°C at 38 mmHg
Density: 1.459 g/mL at 25°C
Refractive Index: n20D 1.47
Flash Point: 46°C
pKa: 7.49 ± 0.10
Solubility: Low solubility in water; soluble in ether, alcohols, and organic solvents
Storage: 2–8°C, sealed, protect from light and moisture
GHS Classification: Warning; H226, H315, H319, H335
Hazard Symbols: Xi – Irritant
Risk Codes: R10, R36/37/38
Safety Description: S16, S26, S36/37/39
WGK Germany: 3
HS Code: 29081990
Transport Classification: UN 1993, Class 3, Packing Group III

Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (1 g, 5 g, 25 g, 100 g) to industrial-scale packaging (500 g, 1 kg, 5 kg, 25 kg) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation with appropriate protection from light, moisture, and ignition sources.

3. Application Fields

As a dual-functional fluorinated phenol building block, 4-Chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6) exhibits wide application value across multiple industries:

Agrochemical Development and Pesticide Manufacturing:

Fundamental scaffold for developing novel herbicides, pesticides, and fungicides
Effective control over various agricultural pests while minimizing environmental impact
Trifluoromethyl group enhances biological activity and metabolic stability of agrochemical active ingredients
Phenolic hydroxyl group enables etherification and esterification for diverse agrochemical structures
Chloro substituent enables cross-coupling reactions for rapid diversification of molecular architectures
Stabilizer in plastics, rubber, dyes, and coatings due to hydroxyl and fluorine content

Pharmaceutical Synthesis and API Manufacturing:

Critical precursor for APIs targeting enzyme inhibition and receptor modulation
Intermediate for pharmaceutical compounds targeting specific health conditions
Privileged building block for medicinal chemistry and drug discovery
Handle for further functionalization via etherification or esterification
Site for cross-coupling reactions to introduce diverse aryl and heteroaryl groups

Advanced Materials and Specialty Coatings:

Formulation of advanced materials with enhanced thermal stability and chemical resistance
Reagent for the synthesis of fluorinated compounds
Component in high-performance coatings, adhesives, and functional polymers
Application in plastics and rubber for improved stability and antioxidant properties

Analytical Chemistry and Research:

Reagent in various analytical techniques for detection and quantification
Valuable tool in academic and industrial research
Facilitates studies in organic chemistry and development of new chemical processes

4. Service Support

Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthetic routes, guidance on handling flammable and moisture-sensitive compounds, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.

Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including compliance with dangerous goods transport regulations (UN 1993, Class 3, PG III), customs clearance, and documentation, with appropriate temperature control (2–8°C) and moisture protection for product stability.

Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, EPA, and other regional regulations, helping customers navigate the complexities of global trade.

5. Reasons to Choose XinChem

Professionalism: Extensive experience and deep expertise in fluorinated phenolic intermediate synthesis and supply.
Quality: Rigorous quality control, high purity (≥96% to ≥98%), and adherence to international standards.
Reliability: Stable supply, competitive pricing, and timely delivery.
Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
Service: Responsive technical support and comprehensive documentation including batch-specific COA.

Website: www.xinchem.com

Email: sales1@xinchem.com

WhatsApp: +86 18049800532

Post time: Oct-04-2026

The Dual-Functional Fluorinated Phenol Building Block for Herbicides, Fungicides, and Pharmaceutical Intermediates: 4-Chloro-3-hydroxybenzotrifluoride (CAS# 40889-91-6)