Quinazoline(CAS#253-82-7)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S23 - Do not breathe vapour. |
| WGK Germany | 3 |
| HS Code | 29339900 |
Introduction
Quinazoline is an organic compound. Here are the details about quinazoline:Quality:Quinazoline is a colorless to light yellow crystalline or crystalline powder;Soluble in alcohols, ethers and ammonia, insoluble in water;Quinazoline is stable in air but tends to produce nitroso compounds when exposed to light.Use:Quinazoline can also be used in the synthesis of dyes, rubber additives, and photosensitive materials.Method:Quinazoline can be prepared by the following reaction pathways:pyrazine reacts with chlorine to form 2,3-dichloropyridine, and then reacts with ammonia to form 2-amino-3-chloropyridine;2-amino-3-chloropyridine is reacted with ketones or alcohols and dehydrated to form quinazoline.Safety Information:Quinazoline has an irritating effect on the skin, eyes, and respiratory tract and should be rinsed with water immediately after exposure. Avoid inhalation and ingestion;During the use of quinazoline, personal protective measures should be taken, gloves, goggles and masks should be worn;When storing quinazoline, it should be kept away from ignition and oxidant, and kept sealed;When using or disposing of quinazoline, follow relevant regulations and safe operating guidelines.
Application
Quinazoline (CAS 253-82-7) is a privileged nitrogen-containing heterocyclic scaffold with a fused benzene-pyrimidine ring system. As a fundamental heterocyclic building block, it serves as the core structure for numerous FDA-approved drugs including gefitinib, erlotinib, and afatinib, which are potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for treating non-small cell lung cancer and other malignancies. Its derivatives exhibit broad-spectrum biological activities: anticancer through kinase inhibition, antihypertensive via α1-adrenoceptor antagonism, antimicrobial, antiviral, anti-inflammatory, anticonvulsant, antimalarial, and antidiabetic effects. The reactive C4 position allows facile nucleophilic aromatic substitution with various nucleophiles, enabling rapid construction of drug-like libraries. In agrochemical research, quinazoline derivatives serve as fungicides and herbicides, while in material science, they are incorporated into polymers, coatings, and fluorescent probes for bioimaging. The quinazoline nucleus acts as a bioisostere for purines, effectively mimicking ATP in kinase active sites, making it a privileged scaffold in medicinal chemistry. Its multicomponent reactivity positions it as an advanced pharmaceutical intermediate for target-oriented synthesis and high-throughput screening campaigns. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity quinazoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
