4,5-Dichloroquinazoline(CAS#2148-55-2)
Introduction
4,5-Dichloroquinazoline is a quinazoline compound containing dichlorosubstitution.By looking at its chemical structure, it is possible to understand the properties of 4,5-dichloroquinazoline. It is a colorless solid with a weak peculiar odor.Due to its special chemical structure, it can be used as an important intermediate to play an important role in the preparation of other organic compounds.The method for preparing 4,5-dichloroquinazoline can be obtained by reacting 2-chloroquinazoline with thionyl chloride. The specific steps include the reaction of 2-chloroquinazoline with thionyl chloride to form an intermediate product, followed by the chlorination reaction of the intermediate product with a mixture of methyl chloride and carbon tetrachloride, and finally crystallization and purification to obtain the target product.The compound may have an irritating effect on the human body, and direct contact with the skin and eyes should be avoided when operating, and operation in a well-ventilated environment should be ensured. Relevant regulations and safe operating procedures should be followed to ensure proper use and storage in laboratories and industrial production.
Application
4,5-Dichloroquinazoline (CAS 2148-55-2) is a functionalized quinazoline derivative featuring chlorine atoms at the 4- and 5-positions. This heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research. The chlorine at C4 undergoes selective nucleophilic aromatic substitution, while the C5 chlorine enables orthogonal cross-coupling reactions (Suzuki, Buchwald-Hartwig), allowing rapid construction of diverse 4,5-disubstituted quinazoline libraries for structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate for developing potent tyrosine kinase inhibitors (e.g., EGFR, HER2, and VEGFR inhibitors) for targeted cancer therapy, as well as antiviral, anti-inflammatory, and antimicrobial agents. Its rigid, planar structure enhances target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4,5-dichloroquinazoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
