5-Fluoropyridine-2-carboxylic acid(CAS#107504-08-5)
| Hazard Symbols | Xi - Irritant |
5-Fluoropyridine-2-carboxylic acid(CAS#107504-08-5)
quality
5-Fluoropyridine-2-carboxylic acid is an organic compound. Here's an introduction to its nature:
Physical properties: 5-fluoropyridine-2-carboxylic acid is a white solid, crystalline at room temperature.
Solubility: 5-Fluoropyridine-2-carboxylic acid is soluble in common polar solvents, such as water, methanol, ethanol, etc. It has low solubility in non-polar solvents.
Acidic: 5-Fluoropyridine-2-carboxylic acid is an organic acid with acidic properties. It can react with a base to produce a corresponding salt, such as sodium 5-fluoropyridine-2-carboxylate.
Chemical reaction: 5-Fluoropyridine-2-carboxylic acid can undergo a variety of reactions such as esterification, reduction, and oxidation in chemical reactions. It can also be used as a starting point for the synthesis of other organic compounds.
Safety Information
5-Fluoropyridine-2-carboxylic acid is an organic compound. The following is safety information about the compound:
1. Toxicity: 5-Fluoropyridine-2-carboxylic acid may be toxic to the human body and needs to be used with caution. Prolonged exposure to its vapours or dust should be avoided.
2. Inhalation: Inhalation of vapor or dust from 5-fluoropyridine-2-carboxylic acid may cause respiratory irritation, causing coughing, difficulty breathing, or transient choking. If discomfort occurs during inhalation, the affected person should be immediately moved to a well-ventilated area and prompt medical attention.
3. Eye contact: 5-Fluoropyridine-2-carboxylic acid entering the eye may cause irritation and pain. In case of contact with eyes, rinse eyes with plenty of water for at least 15 minutes and seek medical attention immediately.
4. Skin contact: Prolonged exposure to 5-fluoropyridine-2-carboxylic acid may cause skin irritation and inflammation. Direct contact should be avoided and, if necessary, protective gloves and clothing should be worn.
5. Environmental impact: 5-fluoropyridine-2-carboxylic acid has a certain risk of pollution to the environment. When using and handling the compound, environmental protection regulations should be followed to avoid its entry into the soil and water sources.
Application
5-Fluoropyridine-2-carboxylic acid (5-Fluoro-2-picolinic acid, CAS 107504-08-5) is a functionalized heterocyclic building block extensively used in pharmaceutical and agrochemical research. In drug discovery, it serves as a key pharmaceutical intermediate for the synthesis of antibacterial agents (e.g., pyridonecarboxylic acids), anticancer compounds, and central nervous system (CNS) drug candidates. The fluorine atom at the 5-position enhances lipophilicity, metabolic stability, and target binding affinity of active pharmaceutical ingredients (APIs). In agrochemistry, this pyridine carboxylic acid scaffold is a critical precursor for novel synthetic auxin herbicides, particularly 4-amino-3-chloro-5-fluoro-2-picolinic acid derivatives used for broad-spectrum weed control. Beyond pharmaceutical and crop protection applications, the carboxylic acid group enables amidation and esterification for rapid structure-activity relationship (SAR) studies, while the fluorinated pyridine ring participates in cross-coupling reactions and nucleophilic substitutions. The compound also finds use in materials science, organic synthesis, and as a radiolabeled imaging agent. Xinchem offers high-purity 5-Fluoropyridine-2-carboxylic acid with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing, scaling from R&D gram quantities to commercial metric tons. Contact us today for a competitive quote and global supply.
