3-(Trifluoromethoxy)fluorobenzene(CAS#1077-01-6)
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1993 |
| Hazard Note | Irritant |
| Hazard Class | FLAMMABLE |
| Packing Group | II |
Introduction
Medifluorotrifluoromethoxybenzene, chemical formula C7H4F4O, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1. Appearance: The fluorine trifluoromethoxybenzene is a white solid.
2. Melting point: about 41-43°C.
3. Boiling point: about 165-168°C.
4. density: about 1.51 g/cm.
5. Solubility: m-Fluorine trifluoromethoxybenzene is soluble in some organic solvents, such as dimethyl sulfoxide and ethanol, but is almost insoluble in water.
Use:
1. as an intermediate: metrifluoromethoxybenzene is often used as an intermediate for the synthesis of other compounds. It can participate in organic synthesis reactions, such as those in the petrochemical and pharmaceutical fields.
2. Catalyst: The compound can also be used as a raw material for organic catalysts.
Preparation Method:
There are many ways to prepare metrifluoromethoxybenzene, one of the common methods is through the reaction of p-trifluoromethyl ether and mefluorobenzonium. Specific reaction conditions and operation steps may vary depending on the preparation method.
Safety Information:
1. The compound may have a certain harmful effect on the human body. For safety reasons, personal protective equipment such as protective gloves, goggles, and laboratory top should be worn when touching or handling the compound.
2. Avoid contact with skin, eyes and respiratory tract. In case of contact, immediately flush the affected area with plenty of water and seek medical assistance.
3. The compound should be stored in a dry, well-ventilated place, away from fire and oxidizing agents.
4. For detailed safety information and operating instructions, please refer to the safety technical instructions of the compound. During use, please abide by the corresponding laws and regulations and safety operation procedures.
Application
3-(Trifluoromethoxy)fluorobenzene (CAS 1077-01-6) is a high-purity, multifunctional fluorinated aromatic building block. Its unique combination of a fluoro substituent and a trifluoromethoxy group (OCF₃) imparts strong electron-withdrawing effects, enhancing the metabolic stability, lipophilicity, and bioavailability of target molecules. This intermediate is widely used in medicinal chemistry for the synthesis of kinase inhibitors, antiviral agents, and central nervous system (CNS) drug candidates. It also serves as a key precursor in agrochemical research for developing next-generation herbicides, fungicides, and insecticides with improved environmental profiles and field efficacy. The compound participates in regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid construction of complex heterocyclic scaffolds. In materials science, it is employed to produce liquid crystal display (LCD) components, specialty polymers, and high-performance coatings. Xinchem offers flexible custom synthesis and contract manufacturing of this essential building block, supporting reliable scale-up from R&D to commercial tons. Contact us for a competitive quote and global supply.
