4-fluorobenzyl alcohol(CAS#459-56-3)
| Risk Codes | R14 - Reacts violently with water R34 - Causes burns R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29062900 |
| Hazard Class | IRRITANT |
Introduction
Fluorobenzyl alcohol is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Properties: Fluorobenzyl alcohol is a colorless liquid with a special aromatic taste. It is soluble in water, and its solubility varies depending on temperature. It is flammable and should be carefully fired. In air, it may be oxidized to benzaldehyde.Uses: Fluorobenzyl alcohol has application value in many fields. It can be used as an important intermediate and catalyst in organic synthesis. Fluorobenzyl alcohol can also be used as a solvent, surfactant, and fragrance component.Preparation method: There are many preparation methods of fluorobenzyl alcohol, which is commonly obtained by fluorinating p-toluene. The specific step can be the reaction of hydrofluoric acid with carbon tetrachloride or trifluorochloromethane, or the use of ferrous fluoride as a fluorinating agent.It is an irritating substance that has an irritating effect on the eyes, skin, and respiratory system. Wear appropriate protective gloves, glasses, and face shields when using and ensure that you operate in a well-ventilated area. Avoid contact with substances such as oxidants and strong alkalis to prevent dangerous reactions. In case of accidental exposure or ingestion, first aid should be taken immediately in case of emergency and medical assistance should be sought.
4-Fluorobenzyl alcohol is a high-purity fluorinated aromatic primary alcohol widely used as a versatile building block in pharmaceutical, agrochemical, and fine chemical synthesis. The electron-withdrawing fluorine atom at the para position enhances metabolic stability and lipophilicity, making it a key intermediate for central nervous system (CNS) drugs, including antidepressants, antipsychotics, and anticonvulsants. It also serves as a precursor for kinase inhibitors, antibacterial agents, and antifungal compounds. The primary alcohol group enables facile oxidation to 4-fluorobenzaldehyde or 4-fluorobenzoic acid, as well as esterification and ether formation, allowing rapid structure-activity relationship (SAR) studies. In agrochemistry, it is utilized to produce selective herbicides and insecticides. Additionally, 4-fluorobenzyl alcohol is employed in the synthesis of liquid crystal materials, specialty polymers, and fragrance ingredients. Xinchem offers custom synthesis and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
