3-fluorobenzyl alcohol(CAS#456-47-3)
| Risk Codes | R14 - Reacts violently with water R34 - Causes burns R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29062900 |
| Hazard Class | IRRITANT |
Introduction
3-fluorobenzyl alcohol is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:Appearance: Colorless liquid or white crystalline solid.Stability: Stable at room temperature, but may cause fire when exposed to open flames, high temperatures, and oxidizing agents.Solubility: Soluble in anhydrous alcohols and ether solvents.Use:It can also be used as a surfactant, disinfectant, preservative, etc.Method:3-Fluorobenzyl alcohol can be prepared by:Fluorination reaction: benzyl alcohol reacts with anhydrous hydrogen fluoride under acidic conditions to produce 3-fluorobenzyl alcohol.Oxidation reaction: Phenylethanol can be obtained by oxidation of oxidant oxygen or hydrogen peroxide under alkaline conditions.Safety Information:3-fluorobenzyl alcohol is a flammable liquid, which should be kept away from open flames and high-temperature heat sources, and stored in a cool and dry place.During use, wear appropriate protective equipment, such as gloves and goggles, and avoid contact with skin and eyes.If ingested or inhaled, seek immediate medical attention.When storing and handling 3-fluorobenzyl alcohol, it should be properly managed in accordance with the requirements of relevant laws and regulations to avoid environmental pollution.
Application
3-Fluorobenzyl alcohol is a high-purity fluorinated aromatic primary alcohol widely used as a versatile building block in pharmaceutical, agrochemical, and fine chemical synthesis. The electron-withdrawing fluorine atom at the meta position enhances metabolic stability, lipophilicity, and bioavailability, making it a key pharmaceutical intermediate for central nervous system (CNS) drugs including antidepressants, antipsychotics, and anticonvulsants. It also serves as a precursor for kinase inhibitors, antibacterial agents, and anti-inflammatory compounds. The primary alcohol group enables facile oxidation to 3-fluorobenzaldehyde or 3-fluorobenzoic acid, as well as esterification and ether formation, allowing rapid structure-activity relationship (SAR) studies. In agrochemical research, it is utilized to produce selective herbicides, fungicides, and insecticides with improved crop protection profiles. Additionally, 3-fluorobenzyl alcohol finds applications in the synthesis of liquid crystal display (LCD) materials, specialty polymers, and fragrance ingredients. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
