4-Quinazolinamine, 6-bromo(CAS#21419-48-7)

Introduction

4-Quinazolinamine, 6-bromo-is an organic compound with the chemical formula C8H6BrN3. It is a white to light yellow solid that is stable at room temperature and pressure.

In terms of its properties, 4-Quinazolinamine, 6-bromo-is a heterocyclic compound whose molecule contains an amino group and a bromine atom. It has good solubility and can be dissolved in a variety of organic solvents. In chemical reactions, it can be used for aromatic electrophilic substitution reactions, nuclear magnetic resonance spectroscopy, mass spectrometry and other applications.

The use of this compound is very extensive. It is used as an important intermediate in the field of medicine and can be used in the synthesis of various potential anti-tumor and anti-viral drugs. In addition, 4-Quinazolinamine, 6-bromo-can also be used to prepare dyes, cosmetic ingredients, pesticides and medical drugs.

Regarding its preparation method, one method is to synthesize 4-Quinazolinamine, 6-bromo-by bromination on quinazolin-4-amine-. In the laboratory, bromide can be obtained by reacting quinazolin-4-amine with a mixed solution of hydrogen bromide gas or bromine.

In terms of safety, 4-Quinazolinamine, 6-bromo-has a certain degree of safety under normal use conditions. However, as a chemical substance, it is still necessary to comply with relevant safety practices, such as wearing appropriate protective equipment, avoiding direct contact with skin and eyes, and avoiding inhalation or ingestion. For specific safety information and risk assessments, reference should be made to the relevant safety data sheets and instructions for use of the chemical.

Application
6-Bromoquinazolin-4-amine (6-bromo-4-quinazolinamine, CAS 21419-48-7) is a functionalized heterocyclic building block featuring an amino group at the 4-position and a bromine atom at the 6-position on the quinazoline core. This compound is widely used in medicinal chemistry and drug discovery for the synthesis of potent tyrosine kinase inhibitors, particularly targeting EGFR, HER2, and VEGFR for treating non-small cell lung cancer, breast cancer, and other malignancies. The bromine enables diverse cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce aryl, heteroaryl, or alkyl groups, while the amino group allows amide, urea, or sulfonamide formation, facilitating rapid structure-activity relationship (SAR) studies. This scaffold is also utilized in the development of antiviral, anti-inflammatory, and antimicrobial agents, as well as in agrochemical research and fluorescent probe synthesis. Its high purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.