2,4,6-Trichloroquinazoline(CAS#20028-68-6)
| Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
Introduction
2,4,6-Trichloroquinazoline is an organic compound.This compound has some of the following properties:Appearance: 2,4,6-trichloroquinazoline is a colorless to pale yellow crystalline solid.Solubility: It has a low solubility in water, but it can be easily dissolved in organic solvents.Stability: 2,4,6-trichloroquinazoline is stable and does not decompose easily at room temperature.The main uses of 2,4,6-trichloroquinazoline are:Fungicide: It has a strong bactericidal effect and can be used as an insecticide and fungicide in agriculture.2,4,6-Trichloroquinazoline can be obtained by the reaction of 2,4,6-trichloropiperazine and ammonium chlorosulfate under suitable conditions.Toxicity: It has a certain toxicity, and it is necessary to follow the corresponding safety operating procedures when using it, and avoid direct contact with the skin or inhalation of its gas.Flammability: 2,4,6-trichloroquinazoline is a combustible substance, and it should be disposed of to avoid ignition and high temperatures.Storage: It should be stored in a dry, cool, well-ventilated place away from direct sunlight.
Application
2,4,6-Trichloroquinazoline (CAS 20028-68-6) is a highly functionalized heterocyclic building block featuring three reactive chlorine atoms at the 2-, 4-, and 6-positions of the quinazoline core. This scaffold enables sequential, site-selective nucleophilic aromatic substitution and cross-coupling reactions, with the C4 chlorine being most reactive, followed by C2 and then C6, allowing orthogonal functionalization to construct diverse polysubstituted quinazoline libraries. It is widely used in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors (e.g., EGFR, HER2, VEGFR, and BTK inhibitors) for targeted cancer therapy, as well as antiviral, anti-inflammatory, and antimicrobial agents. The trichlorinated core also serves as a key intermediate for agrochemicals and fluorescent probes. Its high reactivity and purity ensure reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
