2-Methyl-5-Nitrobenzoic acid(CAS#1975-52-6)
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S22 - Do not breathe dust. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29163900 |
| Hazard Class | IRRITANT |
Introduction
2-methyl-5-nitrobenzoic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2-methyl-5-nitrobenzoic acid is a white crystalline or crystalline powder.- Solubility: Soluble in organic solvents such as ethanol, acetone and xylene, insoluble in water.Use:- Dyes: can be used as a dye raw material for powder and liquid dyes.- Explosives: Can be used to prepare explosives containing nitrogen, such as soft explosives containing high-energy nerve agents.Method:The preparation method of 2-methyl-5-nitrobenzoic acid can be nitrification.- Nitrotoluene can be obtained by nitrification of p-toluene.- Nitrotoluene is then methylated, and 2-methyl-5-nitrobenzoic acid can be obtained by reacting with formic acid and catalyst.Safety Information:2-Methyl-5-nitrobenzoic acid should be stored in a dark, dry and well-ventilated place.- It is a combustible substance and avoids contact with open flames, high temperatures, and oxidizing agents.- Appropriate gloves, protective glasses, and protective clothing should be worn during operation to prevent contact with skin and eyes.- Swallowing or inhaling 2-methyl-5-nitrobenzoic acid may cause poisoning, and if necessary, seek immediate medical attention.
Application
2-Methyl-5-nitrobenzoic acid (CAS 1975-52-6) is a versatile organic intermediate used in pharmaceutical, agrochemical, and fine chemical synthesis. As a key building block, it enables the preparation of non-steroidal anti-inflammatory drugs (NSAIDs), antimicrobial agents, and cardiovascular APIs via amidation, reduction, or esterification reactions. The nitro group can be reduced to an amine for further functionalization, while the carboxylic acid provides a handle for conjugation. In agrochemistry, it serves as a precursor for herbicides and plant growth regulators. This compound also functions as an analytical reference standard for impurity profiling and method validation. High purity ensures reproducible results in drug discovery and scale-up. Xinchem offers custom synthesis and contract manufacturing of this intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote.
