Olivetolic Acid(CAS#491-72-5)

Introduction

2,4-Dihydroxy-6-pentylbenzoic acid, also known as Olivetolic acid, is a chemical compound. Here is some information about this compound:Quality:- Appearance: Colorless to pale yellow solid- Solubility: Slightly soluble in water, soluble in organic solvents such as ether and methanolUse:- Olivetolic Acid is an intermediate in the synthesis of alkaloids in cannabis and one of the important precursors of synthetic cannabinoids.Method:- Olivetolic Acid can be extracted from the hemp plant and can also be prepared by chemical synthesis methods.Safety Information:- Wear appropriate personal protective equipment, such as lab gloves and goggles, to prevent contact with skin and eyes when performing laboratory operations.- When storing and handling, avoid high temperatures, ignition sources, and avoid mixing with chemicals such as oxidants.

Application
Olivetolic acid (OLA; CAS 491-72-5) is the universal polyketide precursor of phytocannabinoid biosynthesis in Cannabis sativa, serving as the essential alkylresorcinolic acid intermediate for constructing the core scaffold of major cannabinoids. As the direct biosynthetic building block for cannabigerolic acid (CBGA) via prenylation with geranyl diphosphate, it serves as the central gateway to CBGA, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabidiol (CBD), and cannabichromene. This foundational pharmaceutical building block is essential for the chemoenzymatic synthesis of standardized cannabinoids and their analogs. In neurological research, OLA displays modest anticonvulsant efficacy by elevating the thermally induced seizure threshold in a Dravet syndrome mouse model at 100 mg/kg. It demonstrates antimicrobial activity against Gram-positive bacteria and inhibitory effects on DNA gyrase and topoisomerase 2 alpha. Furthermore, olivetolic acid functions as a certified analytical reference standard for method development, method validation (AMV), ANDA quality control in cannabinoid analysis, and impurity profiling in pharmaceutical manufacturing. With strong antioxidant, anti-inflammatory, antibacterial, and tyrosinase-inhibitory properties, OLA is also incorporated into cosmetic and skin‑brightening formulations. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity olivetolic acid. Contact us for a competitive quote and global supply.