4-nitro-o-toluic acid(CAS#1975-51-5)

Introduction

2-Methyl-4-nitrobenzoic acid. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 2-Methyl-4-nitrobenzoic acid is a colorless or yellowish crystalline powder.- Solubility: 2-Methyl-4-nitrobenzoic acid is soluble in ethanol, ether and other common organic solvents.- Stability: It is relatively stable, but it decomposes easily in sunlight or high temperatures.Use:- It can also be used as a starting material for some polyester resins.Method:- 2-Methyl-4-nitrobenzoic acid can be obtained by nitrification of p-toluene. Toluene is heated in a mixture of nitric acid and sulfuric acid, and then the reaction products are extracted and crystallized with water to obtain the target product.Safety Information:- 2-Methyl-4-nitrobenzoic acid is a toxic compound that may cause irritating effects and damage to the eyes, skin, and respiratory system when exposed or inhaled.- When handling or storing, appropriate safety measures such as wearing chemical gloves, glasses and masks should be taken to ensure good ventilation.- In case of accidental ingestion or accidental contact, seek medical assistance immediately and provide as many details as possible.

Application
4-Nitro-2-methylbenzoic acid (2-Methyl-4-nitrobenzoic acid, CAS 1975-51-5) is a high-purity aromatic building block widely used as a key pharmaceutical intermediate and organic synthesis reagent. It serves as a critical precursor in the synthesis of Tolvaptan, a selective vasopressin V2 receptor antagonist for treating hyponatremia, and as Tolvaptan Impurity 20, an essential reference standard for analytical method development, method validation (AMV), quality control (QC), and ANDA filings. This versatile intermediate is also employed to synthesize Raf kinase inhibitors targeting melanoma cells and fluorogenic substrates for bioimaging applications. Its utility extends to anti-inflammatory and antibacterial drug discovery, agrochemical development, and the preparation of dyes, pigments, and functional polymers. The nitro group can be reduced to an amine for further derivatization, while the carboxylic acid enables amidation and esterification, supporting rapid structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-Nitro-2-methylbenzoic acid with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.