Methyl 4-methyl-3-nitrobenzoate(CAS#7356-11-8)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | 37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 2 |
| TSCA | Yes |
| HS Code | 29163990 |
Introduction
Methyl 4-methyl-3-nitrobenzoate.Properties: Methyl 4-methyl-3-nitrobenzoate is a yellow liquid with an aromatic taste. The compound is stable at room temperature and soluble in organic solvents.Uses: Methyl 4-methyl-3-nitrobenzoate is often used as a fluorescent dye for pyrotechnics and explosives to increase the fluorescence effect. It can also be used as a raw material for plant growth regulators and pesticides.Method: The preparation of methyl 4-methyl-3-nitrobenzoate can be obtained by reacting p-toluene with nitric acid. Specifically, p-toluene is heated to the reaction temperature and nitric acid is slowly added, and after the reaction is completely cooled, methyl 4-methyl-3-nitrobenzoate can be obtained by separating the product.Safety information: Methyl 4-methyl-3-nitrobenzoate belongs to organic nitrification and has high explosiveness. In the process of use, the relevant safety operation procedures should be strictly adhered to to avoid contact with the fire source and friction. It is also a toxic substance that has an irritating effect on the skin, eyes, and respiratory tract and should be avoided for contact and inhalation. Personal protective equipment such as protective gloves, protective glasses and gas masks should be provided when necessary. During use and storage, maintain good ventilation and keep away from fire sources and oxidants.
Application
Methyl 4-methyl-3-nitrobenzoate (CAS 7356-11-8) is a versatile nitroaromatic ester used as a building block in organic synthesis. It serves as a pharmaceutical intermediate in drug discovery, notably as a synthetic precursor for the anticancer API Nilotinib (Tasigna®) used to treat chronic myelogenous leukemia, and as Lenalidomide Impurity 66 (CAS 7356-11-8), a critical reference standard for analytical method development, method validation (AMV), quality control (QC) in ANDA filings, and forced degradation studies. Beyond pharmaceuticals, the compound is also used in the production of agrochemicals such as herbicides and pesticides, as well as in the synthesis of specialty dyes, pigments, and polymer chemistry. Furthermore, it is employed as a starting material for preparing fluorescent dyes and functional organic chemicals in material science research. Xinchem supports all stages of drug development and chemical manufacturing with reliable custom synthesis, custom chemical synthesis, and flexible contract manufacturing of high‑purity methyl 4-methyl-3-nitrobenzoate, from R&D to commercial supply. Contact us for a competitive quote and dependable global supply.
