4-Methyl-3-nitrobenzoic acid(CAS#96-98-0)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| TSCA | Yes |
| HS Code | 29163990 |
Introduction
3-Nitro-4-methylbenzoic acid is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 3-nitro-4-methylbenzoic acid is a yellow crystal or crystalline powder.- Solubility: It is insoluble in water, but can be dissolved in organic solvents such as ethanol and ether.Use:- Chemical reagents: 3-nitro-4-methylbenzoic acid can be used as a reagent in organic synthesis for the synthesis of other compounds.Method:The common preparation method of 3-nitro-4-methylbenzoic acid is obtained by reacting methylamine and nitric acid under appropriate conditions. For specific steps, please refer to organic synthesis experimental textbooks or related research literature.Safety Information:- 3-Nitro-4-methylbenzoic acid is irritating and should avoid direct contact with the skin and eyes.- During operation and storage, fire sources and high temperatures should be avoided.- Wear appropriate protective gloves, goggles, and respiratory protective equipment when in use.- In case of inhalation or accidental ingestion, seek medical advice immediately and bring the container or label to the hospital.
Application
4-Methyl-3-nitrobenzoic acid (CAS 96-98-0) is a versatile nitroaromatic building block widely used in pharmaceutical and agrochemical R&D. As a key pharmaceutical intermediate, it serves as a precursor for the synthesis of telmisartan (an angiotensin II receptor antagonist for hypertension), as well as other antihypertensive and anti-inflammatory drug candidates. This compound also functions as Telmisartan Impurity B, a critical reference standard for analytical method development, method validation (AMV), quality control (QC), and ANDA filings. In agrochemical research, it is utilized to prepare herbicides, fungicides, and plant growth regulators. Its carboxylic acid and nitro groups allow diverse transformations including amidation, esterification, and reduction to the corresponding aniline, enabling rapid structure-activity relationship (SAR) studies. Additionally, it is used in the synthesis of dyes, pigments, and specialty polymers. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers reliable custom synthesis and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.
