2,5-Difluoroaniline(CAS#367-30-6)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 2941 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29214210 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
2,5-Difluoroaniline.Quality:2,5-Difluoroaniline is a colorless to yellowish crystalline solid. It is stable at room temperature and slightly soluble in water, but easily soluble in organic solvents. It is a hydrophobic amine that has the characteristics of an aromatic amine and is prone to aromatic electron substitution reactions.Use:2,5-Difluoroaniline is often used as an important intermediate and starting substance in organic synthesis. It can also be used as a light-emitting layer material in organic light-emitting diodes (OLEDs).Method:In general, the preparation of 2,5-difluoroaniline can be achieved by introducing a fluorine atom at the position of aminobenzene. One synthesis method is to use chlorofluorodifluoromethane as a fluorine source, react with aminobenzene, and carry out nucleophilic aromatic substitution reaction under alkaline conditions to generate 2,5-difluoroaniline.Safety Information:2,5-Difluoroaniline is a toxic compound that is irritating and corrosive. When using or storing, care should be taken to avoid contact with the skin, eyes and respiratory tract. Appropriate personal protective equipment such as gloves, goggles, and protective clothing should be worn during operation. Avoid contact with strong oxidizing agents and acids to prevent dangerous reactions. When disposing of waste, relevant laws and regulations should be complied with and appropriate disposal measures should be taken.
Application
2,5-Difluoroaniline (CAS 367-30-6) is a crucial fluorinated aromatic building block for the synthesis of advanced pharmaceuticals and agrochemicals. It serves as a key precursor for novel anti-inflammatory agents and drugs targeting neurological and cardiovascular conditions. In oncology, its derivative is a critical intermediate for the KRAS<sup>G12C</sup> inhibitor AZD4625, an anticancer drug candidate for solid tumors. It is also utilized in the formulation of high-efficacy herbicides and pesticides, where the fluorine atoms enhance metabolic stability and uptake. Beyond bioactive compounds, the molecule’s unique electronic properties make it ideal for producing vibrant, stable dyes for textiles and coatings, as well as serving as a monomer for high-performance polymers and resins used in electronics and automotive parts. Additionally, it is a fundamental precursor for imines, Schiff bases, and liquid crystal materials. Xinchem offers high-purity 2,5-Difluoroaniline with flexible custom synthesis, custom chemical synthesis, and contract manufacturing, reliably scaled from R&D to commercial tons. Contact us today for a competitive quote and global supply.







