2-Fluoro-N-methylaniline(CAS#1978-38-7)
| Hazard Symbols | T - Toxic |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29215900 |
Introduction
N-methyl-2-fluoroaniline is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: N-methyl-2-fluoroaniline is a colorless to light yellow liquid.- Solubility: It can be dissolved in most organic solvents such as ethanol, acetone, and methylenebenzene.Use:- N-methyl-2-fluoroaniline is often used as an intermediate in organic synthesis. It can be used in the preparation of compounds with pharmacological activity.- In chemical research, N-methyl-2-fluoroaniline can be used as a fluorination reagent to introduce fluorine atoms.- Due to its specific chemical structure, it can also be used as a photosensitive dye in some organic photographic materials.Method:- N-methyl-2-fluoroaniline is generally prepared by fluorinated aniline. The specific steps include reacting aniline with hydrofluoric acid to obtain N-methyl-2-fluoroaniline.Safety Information:- N-methyl-2-fluoroaniline is an organic compound that is irritating and toxic. Contact with the skin, eyes, or inhalation of its vapors may cause irritation and damage.- Wear protective eyewear, gloves and protective clothing when using. Avoid inhaling its vapors.- Pay attention to well-ventilated conditions when operating and keep the work area clean.- When storing and handling, avoid contact with oxidants, strong acids, etc.
Application
2-Fluoro-N-methylaniline (N-Methyl-2-fluoroaniline, CAS 1978-38-7) is a high-purity fluorinated aniline derivative serving as a key pharmaceutical intermediate and versatile building block in medicinal chemistry. The strategic ortho-fluorine substitution and N-methyl group provide enhanced metabolic stability, lipophilicity, and favorable pharmacokinetic properties. This compound is widely used as an intermediate in the synthesis of pharmaceutical compounds, particularly in the development of drugs targeting neurological disorders, including muscarinic agonists and neuroprotective agents. In drug discovery programs, it enables efficient construction of CNS-active molecules, kinase inhibitors, and analgesic candidates. In agrochemical research, it contributes to the development of effective herbicides and pesticides with improved biological activity. Its utility extends to organic synthesis, dyes, pigments, and the formulation of advanced materials such as fluorinated polymers and high-performance coatings. It also acts as a building block for biologically active molecules in chemical biology research. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 2-Fluoro-N-methylaniline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
