1-Bromo-3-fluoro-4-iodobenzene(CAS#105931-73-5)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
Introduction
1-Bromo-3-fluoro-4-iodobenzene is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:1-Bromo-3-fluoro-4-iodobenzene is a solid that is soluble in organic solvents such as methanol, ethanol and ether.Use:1-Bromo-3-fluoro-4-iodobenzene is often used as an intermediate in organic synthesis.Method:The preparation of 1-bromo-3-fluoro-4-iodobenzene usually uses bromobenzene as a starting material, and fluorine and iodine are introduced into the benzene ring through a series of chemical reactions. The specific reaction path can be optimized according to specific needs, and commonly used methods include substitution reaction, fluorination reaction, and electrophilic substitution reaction.Safety Information:1-Bromo-3-fluoro-4-iodobenzene is a relatively stable compound under general use conditions, but it still needs to be handled safely. It is an organobromine compound that has certain toxicity and irritation. During use, skin contact and inhalation need to be avoided, and appropriate protective gear should be worn if necessary. The compound should be properly stored and disposed of to avoid its leakage or reaction with other hazardous substances. During the treatment, proper operating procedures should be followed and carried out under safe ventilation. It is necessary to formulate corresponding safety operation guidelines according to the specific situation and operate under the guidance of professionals.
Application
1-Bromo-3-fluoro-4-iodobenzene is a highly functionalized trihalogenated benzene derivative that serves as a privileged scaffold for orthogonal cross-coupling chemistry. The iodine and bromine atoms enable sequential, site-selective palladium-catalyzed couplings (Suzuki‑Miyaura, Buchwald‑Hartwig, Sonogashira), with iodine reacting preferentially due to faster oxidative addition, while the fluorine enhances metabolic stability and modulates electronic properties. This advanced building block is widely used in medicinal chemistry for the rapid construction of multi‑substituted arene libraries targeting kinase inhibitors, GPCR modulators, and anticancer agents. It also facilitates the synthesis of biaryl-containing drug candidates, agrochemicals (herbicides, fungicides), and functional materials for organic electronics and liquid crystals. High purity ensures reproducible results in high‑throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote.
