1,3,5-Trifluorobenzene(CAS#372-38-3)

Introduction

1,3,5-Trifluorobenzene is an organic compound. The following is an introduction to its properties, uses, preparation and safety information:Quality:1,3,5-Trifluorobenzene is a colorless liquid with a strong aromatic odor. It is a non-polar solvent that is almost insoluble in water but can be miscible with many organic solvents.Use:1,3,5-Trifluorobenzene is often used as an intermediate in organic synthesis. It can also be used as an organic solvent for dissolving and extracting some compounds.Method:1,3,5-Trifluorobenzene is usually synthesized by fluorination instead of phenyl group. A common preparation method is to react benzene with hydrogen fluoride and use fluorinating agents such as ferric fluoride or cesium fluoride as catalysts to obtain 1,3,5-trifluorobenzene.Safety Information:1,3,5-Trifluorobenzene has no obvious toxicity to the human body at room temperature and pressure, and may have irritating effects on the skin, eyes and respiratory tract. Protective gloves, goggles and respiratory protection should be worn when in use. Avoid inhaling its vapours or dust, and avoid contact with skin and eyes. Attention should be paid to fire and explosion-proof measures during use and storage, and contact with strong oxidants and electrophilic substances should be avoided. In case of accidental contact or inhalation, medical attention should be obtained promptly.

Application
1,3,5-Trifluorobenzene is a high-purity fluorinated aromatic compound serving as a versatile building block for advanced organic synthesis. As a key pharmaceutical intermediate, it is widely used in the synthesis of fluorinated drug candidates, including antiviral and antifungal APIs, where the electron-withdrawing fluorine atoms enhance metabolic stability and bioavailability. In agrochemical research, this intermediate serves as a critical precursor for the production of high-efficacy herbicides and pesticides. Its unique electronic properties and thermal stability make it an ideal precursor for electronic materials, including liquid crystal displays (LCDs) and OLED components, as well as a reactive solvent in specialty polymer formulations. Additionally, 1,3,5-Trifluorobenzene functions as a fluorinated polymer modifier, improving chemical resistance and thermal stability in advanced coatings and engineering plastics. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 1,3,5-Trifluorobenzene with flexible scaling from R&D to commercial tons. Contact us for a competitive quote today.