1,2,4-Trifluorobenzene(CAS#367-23-7)
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S7 - Keep container tightly closed. S33 - Take precautionary measures against static discharges. S29 - Do not empty into drains. S7/9 - |
| UN IDs | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Note | Flammable |
| Hazard Class | 3 |
| Packing Group | II |
Introduction
1,2,4-Trifluorobenzene is an organic compound. It is a colorless liquid that has a smell similar to benzene at room temperature. 1,2,4-Trifluorobenzene has good thermal properties and chemical resistance, and is a commonly used solvent.1,2,4-Trifluorobenzene is used as a solvent or reaction intermediate in many chemical reactions. Due to its low odor threshold and minimal volatility, 1,2,4-trifluorobenzene is also used as a cleaning agent and solvent for electronics.There are several ways to prepare 1,2,4-trifluorobenzene. A common approach is to introduce benzene into a fluoride-containing reaction and use a fluorinating agent to initiate the substitution reaction. Another method is to convert benzene into 1,2,4-trinitrobenzene, which is then prepared by reduction and fluorination reactions.Safety information: 1,2,4-trifluorobenzene is irritating to the skin and eyes, and should be rinsed with water in time after contact. It is low in volatility and may cause respiratory irritation and dizziness when inhaled for a long time. Appropriate precautions should be used during operation, including wearing protective glasses and gloves. When storing and handling 1,2,4-trifluorobenzene, follow the relevant safety operating procedures and keep it away from open flames and heat sources.
Application
1,2,4-Trifluorobenzene (CAS 367-23-7) is a versatile fluorinated building block widely used in pharmaceutical, agrochemical, and electronic material research. As a key intermediate in drug discovery, its introduction of fluorine enhances metabolic stability, lipophilicity, and bioavailability of drug candidates, particularly in the synthesis of antiviral and anticancer therapeutic drugs. In crop protection, 1,2,4-trifluorobenzene serves as a crucial precursor for developing high-efficacy herbicides, fungicides, and pesticides, where fluorine substitution improves the anti-degradation ability and target selectivity of active ingredients. The compound is also utilized in the synthesis of liquid crystal display materials, enhancing electro-optical properties such as resolution, contrast, and response speed. In material science, it contributes to advanced polymers and coatings, offering enhanced durability and solvent resistance, and serves as a specialty solvent for electronic components and analytical chromatography. Its electron-deficient arene structure enables regioselective nucleophilic aromatic substitution and cross-coupling reactions. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 1,2,4-trifluorobenzene with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
