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3-chloro-4-fluorotoluene(CAS#1513-25-3)

Chemical Property:

Molecular Formula C7H6ClF
Molar Mass 144.57
Density 1.182g/mLat 25°C(lit.)
Boling Point 167-169°C(lit.)
Flash Point 131°F
Vapor Presure 2.31mmHg at 25°C
Specific Gravity 1.18
Storage Condition Sealed in dry,Room Temperature
Refractive Index n20/D 1.501(lit.)
Physical and Chemical Properties Colorless to light yellow liquid

Product Detail

Product Tags

Risk Codes R10 - Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S16/26/36 -
UN IDs UN 1993 3/PG 3
WGK Germany 3
Hazard Note Irritant/Flammable
Hazard Class 3.2
Packing Group III

 

Introduction

3-choro-4-fluorotoluene is an organic compound with the chemical formula C7H6ClF. It is a colorless liquid with a pungent odor at room temperature. Here are some of the properties and uses of 3-choro-4-fluorotoluene:

 

Nature:

-Boiling point: 141-142 ° C

-Melting point:-31 ° C

-Density: 1.24g/cm3

-Solubility: Soluble in organic solvents, insoluble in water.

 

Use:

-As an organic intermediate: 3-choro-4-fluorotoluene can be used to synthesize other organic compounds, such as pesticides, drugs and dyes.

-Reagent: It can also be used as a reagent for some organic chemical reactions, such as acylation reactions and aromatic substitution reactions.

 

Method:

3-chloro-4-fluorotoluene can be prepared by fluorinating 3-chlorotoluene. 3-Chlorotoluene is first reacted with a fluorinating agent, and the reaction is carried out under appropriate conditions to produce 3-chloro-4-fluorotoluene.

 

Safety Information:

-3-choro-4-fluorotoluene is an irritating compound that may cause irritation and inflammation when in contact with the skin and eyes. Wear appropriate protective equipment such as gloves and goggles during use.

-it is a flammable liquid, away from the fire and high temperature environment.

-storage, should be stored in a cool, ventilated place, away from oxidants.

-Observe safe operating procedures and local regulations when using and handling. If ingested or inhaled, seek medical attention immediately.

Application
3-Chloro-4-fluorotoluene (CAS 1513-25-3) is a versatile fluorinated building block used as a pharmaceutical intermediate in the synthesis of anti-cancer, anti-inflammatory, and antiviral APIs. As an agrochemical intermediate, it enables the production of selective herbicides and broad-spectrum fungicides. Its electron-deficient aromatic ring with orthogonal halogens facilitates regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-couplings (Suzuki, Stille, Heck). The methyl group can be oxidized to the carboxylic acid for further derivatization. It also serves as a key precursor for fluorinated liquid crystal monomers in display materials and specialty dyes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3-chloro-4-fluorotoluene with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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