3-chloro-4-fluorotoluene(CAS#1513-25-3)
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S16/26/36 - |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| Hazard Note | Irritant/Flammable |
| Hazard Class | 3.2 |
| Packing Group | III |
Introduction
3-choro-4-fluorotoluene is an organic compound with the chemical formula C7H6ClF. It is a colorless liquid with a pungent odor at room temperature. Here are some of the properties and uses of 3-choro-4-fluorotoluene:
Nature:
-Boiling point: 141-142 ° C
-Melting point:-31 ° C
-Density: 1.24g/cm3
-Solubility: Soluble in organic solvents, insoluble in water.
Use:
-As an organic intermediate: 3-choro-4-fluorotoluene can be used to synthesize other organic compounds, such as pesticides, drugs and dyes.
-Reagent: It can also be used as a reagent for some organic chemical reactions, such as acylation reactions and aromatic substitution reactions.
Method:
3-chloro-4-fluorotoluene can be prepared by fluorinating 3-chlorotoluene. 3-Chlorotoluene is first reacted with a fluorinating agent, and the reaction is carried out under appropriate conditions to produce 3-chloro-4-fluorotoluene.
Safety Information:
-3-choro-4-fluorotoluene is an irritating compound that may cause irritation and inflammation when in contact with the skin and eyes. Wear appropriate protective equipment such as gloves and goggles during use.
-it is a flammable liquid, away from the fire and high temperature environment.
-storage, should be stored in a cool, ventilated place, away from oxidants.
-Observe safe operating procedures and local regulations when using and handling. If ingested or inhaled, seek medical attention immediately.
Application
3-Chloro-4-fluorotoluene (CAS 1513-25-3) is a versatile fluorinated building block used as a pharmaceutical intermediate in the synthesis of anti-cancer, anti-inflammatory, and antiviral APIs. As an agrochemical intermediate, it enables the production of selective herbicides and broad-spectrum fungicides. Its electron-deficient aromatic ring with orthogonal halogens facilitates regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-couplings (Suzuki, Stille, Heck). The methyl group can be oxidized to the carboxylic acid for further derivatization. It also serves as a key precursor for fluorinated liquid crystal monomers in display materials and specialty dyes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3-chloro-4-fluorotoluene with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.




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