2-Chloro-6-fluorotoluene(CAS#443-83-4)
| Risk Codes | R10 - Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 2 |
| TSCA | T |
| HS Code | 29039990 |
| Hazard Note | Irritant/Flammable |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2-Chloro-6-fluorotoluene is an organic compound. It is a colorless liquid with a sweet taste and a benzene-like odor. The following is an introduction to the properties, uses, preparation methods and safety information of 2-chloro-6-fluorotoluene:Quality:- Appearance: Colorless liquid- Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and acetone.Use:- 2-Chloro-6-fluorotoluene is an important chemical raw material, which is widely used in organic synthesis and pharmaceutical industry.- It can be used as a fluorinating agent, fluorinated reagent and a substitute for aromatic hydrocarbons.- In agriculture, it is also used as an insecticide and fungicide.Method:- 2-Chloro-6-fluorotoluene is generally obtained by the reaction of benzoic acid and hydrofluoric acid.- Specifically, benzoic acid is first reacted with hydrofluoric acid to form benzoyl fluoride, and then further fluorination is carried out under acidic conditions to obtain 2-chloro-6-fluorotoluene.Safety Information:- 2-Chloro-6-fluorotoluene is an irritating compound that should be avoided from contact with skin and eyes.- During operation, good ventilation measures should be taken and appropriate respiratory protective equipment should be worn.- In the event of an accidental leak, follow the appropriate emergency treatment methods and contact a professional for handling.It is important to dispose of 2-chloro-6-fluorotoluene in a laboratory or industrial setting in accordance with safe operating procedures.
Application
2-Chloro-6-fluorotoluene (CFT, CAS 443-83-4) is a highly valuable halogenated aromatic intermediate. It serves as a critical pharmaceutical building block in the synthesis of Delamanid, a key anti-tuberculosis agent, and is also utilized in the production of anti-inflammatory drugs (e.g., Celecoxib) and antipsychotics (e.g., Aripiprazole). In the agrochemical sector, it is an essential precursor for the plant growth regulator Flumetralin and contributes to the synthesis of herbicides like florasulam and various fungicides. Its unique ortho-chloro and ortho-fluoro substitution pattern enables precise functionalization into amines, alcohols, nitriles, and carboxylic acids, making it a versatile precursor for constructing complex drug-like scaffolds. Xinchem is a premier manufacturer and supplier of high-purity 2-chloro-6-fluorotoluene. We offer flexible custom synthesis and reliable contract manufacturing, with full regulatory support, scaled from R&D quantities to commercial tons. Contact us today for a competitive quote.



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