3,4-Difluoroaniline(CAS#3863-11-4)
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2941 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CX9871900 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29214200 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
3,4-Difluoroaniline is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 3,4-difluoroaniline:Quality:- Appearance: 3,4-Difluoroaniline is a colorless or light yellow crystalline powder.- Solubility: Soluble in organic solvents such as alcohols, ethers and chlorinated hydrocarbons, slightly soluble in water.Use:- Pigments: Due to their special chemical structure, 3,4-difluoroaniline can also be used to prepare organic pigments.Method:- 3,4-difluoroaniline is generally prepared by heating and reduction in the presence of 3,4-difluoronitrobenzene and iridium complexes in a hydrogen atmosphere.Safety Information:- 3,4-Difluoroaniline should be used or stored with the following safety precautions:- Avoid inhaling dust or contact with skin and eyes.- Wear appropriate protective gloves, goggles, and masks when operating.- Avoid contact with strong oxidizing agents and combustibles to avoid fire or explosion.
Application
3,4-Difluoroaniline is a high-purity fluorinated aromatic amine widely used as a key building block in pharmaceutical, agrochemical, and materials research. In drug discovery, it serves as a crucial pharmaceutical intermediate for the synthesis of fluoroquinolone antibiotics (e.g., ciprofloxacin analogs), anticancer agents (e.g., EGFR and kinase inhibitors), and antiviral compounds. The electron-withdrawing fluorine atoms enhance metabolic stability, lipophilicity, and target binding affinity. In agrochemical development, this versatile aniline derivative is utilized to prepare selective herbicides, fungicides, and insecticides with improved crop protection profiles and environmental safety. Its aromatic amine functionality enables diazotization, nucleophilic aromatic substitution, and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig) for rapid structure-activity relationship (SAR) studies. Additionally, it is employed in the synthesis of specialty dyes, pigments, and fluorinated polymers with enhanced thermal and chemical resistance. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of 3,4-difluoroaniline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and global supply.
