3,5-Difluoroaniline(CAS#372-39-4)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1325 4.1/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29214200 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
3,5-Difluoroaniline is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 3,5-Difluoroaniline is a white crystalline solid.- Solubility: It has low solubility in water and better solubility in organic solvents.Use:- Chemical reagents: 3,5-difluoroaniline is often used as a raw material and intermediate in organic synthesis.- Fluorescent dye: With its special structure, 3,5-difluoroaniline can be used to prepare fluorescent dyes for fluorescence display, biological imaging and other fields.Method:3,5-Difluoroaniline can be prepared by aniline and fluorinating agents (e.g., hydrogen fluoride) under reaction conditions. This can usually be achieved with the catalysis of an acidic catalyst.Safety Information:- Toxicity: 3,5-Difluoroaniline may be toxic to humans, skin contact and inhalation should be avoided.- Flammability: It is flammable and may produce toxic gases when exposed to an open flame or high heat.- Storage precautions: Store in an airtight container, away from fire and oxidants.For specific operation details, please refer to the relevant chemistry manual or consult a professional.
Application
3,5-Difluoroaniline (CAS 372-39-4) is a high-purity, fluorinated aromatic amine used as a key intermediate in pharmaceutical and agrochemical R&D, as well as in material science. As a versatile scaffold, it enables efficient access to fluorinated drug candidates via palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig) and nucleophilic aromatic substitution. It is widely used in the synthesis of active pharmaceutical intermediates (APIs) targeting neurological and cardiovascular conditions, and in the development of agrochemicals such as broadleaf herbicides and fungicides, where the fluorine substituents enhance metabolic stability, binding affinity, and environmental profile. Additionally, it serves as a building block for specialty dyes, pigments, and fluorinated polymers with high thermal/chemical resistance. As a fragment molecule, it provides an ideal structural basis for molecular linking in drug discovery. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential compound with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.
