4-Bromo-2-fluoroaniline(CAS#367-24-8)
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29214200 |
| Hazard Class | IRRITANT |
Introduction
4-Bromo-2-fluoroaniline is an organic compound with the formula C6H5BrFN. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Bromo-2-fluoroaniline is a white to pale yellow solid.
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide, insoluble in water.
Use:
-Chemical synthesis: 4-Bromo-2-fluoroaniline is an important intermediate, which is widely used in the synthesis of drugs and pesticides.
-Organic synthesis: It can be used as a fluorinating agent for fluorination reactions in organic synthesis.
Preparation Method:
4-Bromo-2-fluoroaniline is generally synthesized by the following steps:
1. using aniline as raw material, using oxidation reagent to oxidize aniline to phenol.
2. 4-bromophenol is obtained by bromination of phenol.
3. 4-Bromophenol is reacted with a fluorinating reagent to form 4-Bromo-2-fluoroaniline.
Safety Information:
- 4-Bromo-2-fluoroaniline is a chemical and must be used in accordance with safety procedures.
-It may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment when using it.
-Avoid breathing gas, eating or touching skin. If contact occurs, immediately flush the affected area with water and seek medical help.
-During storage and transportation, it should be kept isolated from other substances, and the packaging should be properly sealed, away from fire and heat sources.
Please note that the above information is for reference only. Please read the product label and technical instructions carefully during specific operation and use, and follow relevant safety instructions.
Application
4-Bromo-2-fluoroaniline (CAS 367-24-8) is a halogenated aniline building block widely used in pharmaceutical, agrochemical, and material science research. In drug discovery, it serves as a key pharmaceutical intermediate for the synthesis of 4-anilinoquinazoline derivatives, which are potent anticancer agents that selectively inhibit EGFR and VEGFR tyrosine kinases involved in cancer cell growth and angiogenesis. It has also been employed as a precursor in the synthesis of monoacylglycerol acyltransferase 2 (MGAT2) inhibitors for antidiabetic research to reduce triglyceride levels. In agrochemical development, the fluorine and bromine substituents contribute to the stability and efficacy of herbicides and crop protection products. In materials science, this compound enables diazotization and coupling reactions to produce biaryl dyes, pigments, and functional polymers. As a versatile organic building block, it participates in palladium-catalyzed cross-coupling reactions (Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution (SNAr). It is also used as an analytical reference standard in chromatography for pharmaceutical quality control and impurity profiling. Xinchem offers high-purity 4-Bromo-2-fluoroaniline with comprehensive analytical characterization (HPLC, GC, NMR) and flexible scaling from R&D grams to commercial metric tons, supported by reliable contract manufacturing and custom synthesis capabilities. Contact us for a competitive quote and global supply.
