2-Methyl-3-nitrophenol(CAS#5460-31-1)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2446 6.1/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29089000 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
2-Hydroxy-6-nitrotoluene. The following is an introduction to the properties, uses, preparation methods and safety information of this compound: Properties: 2-hydroxy-6-nitrotoluene is an organic compound with yellow or brown crystals in appearance and a special aromatic odor. It is insoluble in water but soluble in organic solvents such as ethanol, ether and benzene. It is sensitive to thermal stability and prone to combustion. Uses: 2-hydroxy-6-nitrotoluene can be used as an intermediate in organic synthesis. It is mainly used in the preparation of dyes, pigments, and fluorescent dyes, etc. Preparation method: The preparation of 2-hydroxy-6-nitrotoluene is usually obtained by the reaction of benzoyl chloride and nitric acid. The specific step is to react benzoyl chloride with nitric acid to produce 2-hydroxy-6-nitrotoluene. Safety information: 2-hydroxy-6-nitrotoluene is a toxic substance. Exposure, inhalation, or excessive ingestion can be harmful to humans. It can cause irritation to the skin, eyes, and respiratory system. Personal protection is required during handling and use, such as wearing protective gloves, goggles, and respiratory protective equipment. During storage and transportation, contact with organic matter, ignition sources and oxidants should be avoided to prevent fire or explosion.
Application
2-Methyl-3-nitrophenol (3-nitro-2-methylphenol, CAS 5460-31-1) is a functionalized nitrophenol derivative serving as a versatile intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. It is used to construct bioactive molecules, including anti-inflammatory, analgesic, and antimicrobial agents. The phenolic hydroxyl allows esterification and ether formation, while the nitro group can be reduced to an amine for further derivatization, enabling rapid access to heterocyclic scaffolds such as benzoxazoles and quinoxalines. In agrochemistry, it is a precursor for herbicides, fungicides, and insecticides. It also finds use in dye manufacturing and as a building block for specialty polymers and coordination complexes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-methyl-3-nitrophenol with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
