(+/-)-Corey lactone diol(CAS#54423-47-1)

Introduction

Corey lactone diol (Corey lactone diol) is a chiral organic compound, there are two optical isomers, respectively () and (-). Its chemical formula is C8H14O3.

Properties: Corey lactone diol is a colorless solid, soluble in organic solvents such as ether, dimethylformamide, etc. It has two alcohol groups and a lactone ring, and these functional groups give it a certain reactivity.

Purpose: Corey lactone diol is an important intermediate in organic synthesis and is widely used in organic synthesis. It can be used to prepare chiral drugs, pesticides and other bioactive molecules. In addition, it can also be used as a light removal mechanism and other materials synthesis and research.

Preparation method: Corey lactone diol has various preparation methods. Commonly used methods include Corey-Binski reaction, direct ester condensation, etc. In these reactions, a chiral auxiliary reagent or catalyst is often reacted with a compound having an aldehyde group or a ketone group to synthesize a chiral cori lactone diol.

Safety information: Corey lactone diol has low toxicity, but it is still necessary to pay attention to its correct use and storage. Wear protective gloves and goggles during use to avoid inhalation, ingestion or contact with skin. Should be sealed in storage, and placed in a cool, dry, well-ventilated place, away from fire and flammable materials. Any specific information about the use of this compound should be obtained in the specific product safety data sheet (MSDS). Please ensure that proper safety practices and laboratory regulations are followed in laboratory work.

Application
(±)-Corey lactone diol is a racemic bicyclic γ-lactone and a critical intermediate for the synthesis of prostaglandins (PGs) and their analogs, as exemplified by the core structure of the anti‑glaucoma drug Bimatoprost. Its rigid, enantiomerically pure scaffold allows selective transformations, enabling the construction of the entire range of natural and synthetic prostanoids as well as other complex natural products. In pharmaceutical R&D, this chiral building block is indispensable for developing PG analogs used in ophthalmology, reproductive health, and cardiovascular therapies. The two hydroxyl groups and the lactone ring serve as versatile handles for side‑chain attachment, functional‑group interconversion, and stereochemical control, making (±)-Corey lactone diol a premier intermediate for drug‑discovery programs and for the manufacture of PG-based APIs under GMP guidelines. Xinchem offers high‑purity (±)-Corey lactone diol with flexible custom synthesis and contract manufacturing, scaled reliably from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.