Methyl 3,5-dibromopyrazine-2-carboxylate(CAS#1035818-91-7)
Introduction
Methyl 3,5-dibromopyrazine-2-carboxylic acid is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- Appearance: Colorless to pale yellow crystals or solids.- Solubility: Soluble in some organic solvents, such as methylene chloride, dimethyl sulfoxide and ether.Use:- Methyl 3,5-dibromopyrazine-2-carboxylic acid can be used as an intermediate in organic synthesis.- It can also be used as a coordination reagent, surfactant, etc.Method:- The preparation of methyl 3,5-dibromopyrazine-2-carboxylic acid generally involves a multi-step reaction.- A common preparation method is to react 3,5-dibromopyrazine with methanol, and then undergo acid-catalyzed esterification to obtain the product.Safety Information:- Methyl 3,5-dibromopyrazine-2-carboxylic acid is an organohalogen compound and has certain hazards.- When using or storing, care should be taken to avoid contact with oxidizing agents, high temperatures, and open flames to prevent fire or explosion.- Wear appropriate protective measures such as protective eyewear, protective gloves, and lab coats when using.- When handling the compound, good ventilation should be taken and inhalation or skin contact should be avoided.- In case of skin or eye contact, rinse immediately with plenty of water and seek medical assistance.
Application
Methyl 3,5-dibromopyrazine-2-carboxylate (CAS 1035818-91-7) is a high‑purity, dihalogenated pyrazine building block widely used in medicinal chemistry and drug discovery. The two bromine atoms enable orthogonal, regioselective palladium‑catalyzed cross‑coupling reactions (Suzuki‑Miyaura, Buchwald‑Hartwig, Sonogashira) to rapidly install diverse aryl, heteroaryl, or alkyl substituents. The methyl ester provides a versatile handle for hydrolysis to the carboxylic acid or reduction to the alcohol, facilitating further derivatization. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, antibacterial compounds, and anti‑inflammatory drug candidates. Its rigid pyrazine core offers excellent metabolic stability and target binding affinity, enabling rapid structure‑activity relationship (SAR) studies. It is also utilized in agrochemical research for developing herbicides and fungicides. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
