methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate,hydrochloride(CAS#220247-69-8)

Introduction

Methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid hydrochloride is an organic compound. The following describes its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless crystalline solid- Solubility: It is difficult to dissolve in water, and it is soluble in organic solvents such as alcohol and dimethylformamideUse:- 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid methyl hydrochloride is often used as an intermediate in organic synthesis. The specific use depends on the target structure of the compound.Method:- The preparation method of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid methyl ester hydrochloride is complex, and a common preparation method is to react 1,2,3,4-tetrahydroisoquinoline with methyl formate in the presence of hydrochloric acid to produce it through chemical reaction.Safety Information:- Wear appropriate personal protective equipment, such as lab gloves and goggles, and avoid direct contact with skin and eyes during handling.- This compound should be stored in a dry, well-ventilated place, away from ignition and oxidants.- Please refer to the relevant Safety Data Sheet (MSDS) for more detailed safety information.

Application
Methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride (CAS 220247-69-8) is a functionalized tetrahydroisoquinoline (THIQ) derivative featuring a methyl ester at the 7-position and supplied as a stable hydrochloride salt. This heterocyclic building block is widely used in medicinal chemistry and pharmaceutical research as a key intermediate for the synthesis of bioactive molecules targeting the central nervous system (CNS), including potential treatments for Parkinson’s disease, Alzheimer’s disease, depression, and anxiety. The ester group enables facile hydrolysis to the corresponding carboxylic acid, which can then undergo amide bond formation for rapid structure-activity relationship (SAR) studies. The THIQ core is a privileged scaffold found in many natural alkaloids and drug candidates, and this intermediate also serves as a precursor for kinase inhibitors, GPCR modulators, and neuroprotective agents. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.