(R)-2,5-dihydro-3,6-dimethoxy-2-iso-propylpyrazine(CAS#109838-85-9)
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 2933 99 80 |
Application
(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (CAS 109838-85-9) is the renowned Schöllkopf chiral auxiliary, a bislactim ether derived from D-valine that serves as a glycine equivalent for the asymmetric synthesis of a wide range of non-natural and alpha-deuterated alpha-amino acids. This compound is widely utilized in medicinal chemistry and pharmaceutical R&D to generate optically active building blocks for peptide-based drugs, enzyme inhibitors, and complex natural products. The chiral auxiliary enables highly diastereoselective alkylation, aldol, and Michael addition reactions, after which it can be cleaved under mild acidic conditions to liberate enantiomerically pure alpha-amino esters. Beyond amino acid synthesis, this scaffold has proven effective for constructing tryptophan analogs, heteroaromatic alanines, and constrained cyclic amino acid derivatives essential for modern drug discovery. Because of its broad utility in custom chemical synthesis, this reagent is indispensable for pharmaceutical, agrochemical, and biotechnology research programs requiring advanced, tailor-made alpha-amino acids and peptide intermediates. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
